ARF: connecting senescence and innate immunity for clearance

We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as we...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2015-09, Vol.7 (9), p.613-615
Main Authors: Kearney, Alper Y, Anchang, Benedict, Plevritis, Sylvia, Felsher, Dean W
Format: Article
Language:English
Subjects:
ADP-Ribosylation Factor 1 - genetics
Aging - genetics
Animals
Genes, p53
Humans
Immunity, Innate - genetics
Oncogenes - genetics
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Summary:We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.100813