Glucocorticosteroids do not impact directly growth rate and biomass of Rhizopus arrhizus (syn. R. oryzae) in vitro

Glucocorticoid (GC) use is a common risk factor for invasive fungal infections. This is attributed to the complex dysregulation of immunity caused by GCs. However, studies have demonstrated increased growth with GC exposure for some molds, such as Aspergillus fumigatus and Exserohilum rostratum. No...

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Bibliographic Details
Published in:Virulence 2015-01, Vol.6 (5), p.441-443
Main Authors: Bellanger, A P, Minetos, Y D, Albert, N, Shirazi, F, Walsh, T J, Kontoyiannis, D P
Format: Article
Language:English
Subjects:
Biomass
Brief Report
Culture Media - chemistry
Dexamethasone - pharmacology
Ecology, environment
Glucocorticoids - pharmacology
Health
Hydrocortisone - pharmacology
Life Sciences
Mucormycosis - microbiology
Prednisone - analogs & derivatives
Prednisone - pharmacology
Rhizopus - drug effects
Rhizopus - growth & development
Rhizopus - metabolism
Spectrophotometry
Spores, Fungal - drug effects
Spores, Fungal - growth & development
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Summary:Glucocorticoid (GC) use is a common risk factor for invasive fungal infections. This is attributed to the complex dysregulation of immunity caused by GCs. However, studies have demonstrated increased growth with GC exposure for some molds, such as Aspergillus fumigatus and Exserohilum rostratum. No such data exist for Mucorales. Therefore, we investigated the influence of GC exposure on the growth of Rhizopus arrhizus (syn. R. oryzae) in different culture media and in different atmospheres. We measured continuous spore growth using spectrophotometry and biomass variations using XTT assay. We did not observe enhanced growth or biomass variation with any of the GCs regardless of the medium or conditions. These results support the existence of fungus-specific differences in the effect of GCs on fungal biology.
ISSN:2150-5594
2150-5608
DOI:10.1080/21505594.2015.1039762