Early Diagnosis and Successful Treatment of Cryptococcus albidus Keratitis: A Case Report and Literature Review

Cryptococcus albidus keratitis is a rare and difficult diagnosed disease. Here we report a case of C albidus keratitis early diagnosed by dot hybridization assay and successfully treated with intrastromal injection of Amphotericin B (AB).A 45-year-old man presented with left red eye for 2 days. The...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2015-05, Vol.94 (19), p.e885-e885
Main Authors: Huang, Yi-Hsun, Lin, I-Huang, Chang, Tsung-Chain, Tseng, Sung-Huei
Format: Article
Language:English
Subjects:
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Clinical Case Report
Cryptococcosis - diagnosis
Cryptococcosis - drug therapy
Early Diagnosis
Humans
Keratitis - diagnosis
Keratitis - drug therapy
Keratitis - microbiology
Male
Middle Aged
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cryptococcus albidus keratitis is a rare and difficult diagnosed disease. Here we report a case of C albidus keratitis early diagnosed by dot hybridization assay and successfully treated with intrastromal injection of Amphotericin B (AB).A 45-year-old man presented with left red eye for 2 days. The slit lamp examination exhibited deep corneal infiltrations. Smears and cultures were performed but revealed negative findings. Molecular detection of pathogens was performed by dot hybridization assay, and C albidus keratitis was diagnosed. Despite the identification of C albidus, the clinical condition still worsened due to deep corneal infiltration. After performing intrastromal injection of AB, the corneal infiltration gradually improved.C albidus is a rare cause of diseases in humans and should be considered as a potential pathogen of corneal ulcer. The prognosis of C albidus keratitis will improve if the condition is recognized early and treated properly.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000000885