Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer

Prostate cancer is the second leading cause of cancer-related death in men in most Western countries. In this report, we present 2 cases of metastatic castration-resistant prostate cancer and chronic kidney disease. Both patients underwent and developed clinical resistance to androgen-deprivation th...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2014-12, Vol.93 (27), p.e163-e163
Main Authors: Francini, Edoardo, Petrioli, Roberto, Fiaschi, Anna Ida, Laera, Letizia, Roviello, Giandomenico
Format: Article
Language:English
Subjects:
Adenocarcinoma - complications
Adenocarcinoma - drug therapy
Aged
Androstenes
Androstenols - therapeutic use
Antineoplastic Agents - therapeutic use
Clinical Case Report
Humans
Kidney Function Tests
Male
Middle Aged
Prostatic Neoplasms - complications
Prostatic Neoplasms - drug therapy
Renal Insufficiency, Chronic - complications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prostate cancer is the second leading cause of cancer-related death in men in most Western countries. In this report, we present 2 cases of metastatic castration-resistant prostate cancer and chronic kidney disease. Both patients underwent and developed clinical resistance to androgen-deprivation therapy. Subsequently, the patients were treated with the conventional chemotherapeutic approach, which resulted in the worsening of renal function and performance status. Therefore, we opted for treatment with abiraterone acetate, and the patients exhibited improvements in renal function with good response of the disease.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000000163