Diffuse Interstitial Brain Edema in Patients With End-Stage Renal Disease Undergoing Hemodialysis: A Tract-Based Spatial Statistics Study

• Published in: Medicine (Baltimore) 2014-12, Vol.93 (28), p.e313-e313
• Main Authors: Kong, Xiang, Wen, Ji-qiu, Qi, Rong-feng, Luo, Song, Zhong, Jian-hui, Chen, Hui-juan, Ji, Gong-jun, Lu, Guang Ming, Zhang, Long Jiang
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Brain - pathology; Brain Edema - diagnosis; Brain Edema - etiology; Diagnosis, Differential; Diffusion Tensor Imaging - methods; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - diagnosis; Male; Middle Aged; Neuropsychological Tests; Observational Study; Prospective Studies; Renal Dialysis - adverse effects; Reproducibility of Results; Young Adult
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000000313

To investigate white matter (WM) alterations and their correlation with cognition function in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) using diffusion tensor imaging (DTI) with tract-based spatial statistics (TBSS) approach. This prospective HIPAA-complaint study was approved by our institutional review board. Eighty HD ESRD patients and 80 sex- and age-matched healthy controls were included. Neuropsychological (NP) tests and laboratory tests, including serum creatinine and urea, were performed. DTI data were processed to obtain fractional anisotropy (FA) and mean diffusivity (MD) maps with TBSS. FA and MD difference between the 2 groups were compared. We also explored the associations of FA values in WM regions of lower FA with ages, NP tests, disease, and dialysis durations, serum creatinine and urea levels of ESRD patients. Compared with controls, HD ESRD patients had lower FA value in the corpus callosum, bilateral corona radiate, posterior thalamic radiation, left superior longitudinal fasciculus, and right cingulum (P