Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol

Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms,...

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Bibliographic Details
Published in:Thorax 1986-04, Vol.41 (4), p.290-294
Main Authors: Johnson, C E, Belfield, P W, Davis, S, Cooke, N J, Spencer, A, Davies, J A
Format: Article
Language:English
Subjects:
Adult
Albuterol - therapeutic use
Asthma - physiopathology
Asthma, Exercise-Induced - blood
Asthma, Exercise-Induced - physiopathology
Asthma, Exercise-Induced - prevention & control
beta-Thromboglobulin - analysis
Biological and medical sciences
Blood Platelets - physiology
Cromolyn Sodium - therapeutic use
Humans
Medical sciences
Peak Expiratory Flow Rate
Pharmacology. Drug treatments
Platelet Factor 4 - analysis
Respiratory system
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Summary:Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.41.4.290