Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol

Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms,...

Full description

Saved in:
Bibliographic Details
Published in:Thorax 1986-04, Vol.41 (4), p.290-294
Main Authors: Johnson, C E, Belfield, P W, Davis, S, Cooke, N J, Spencer, A, Davies, J A
Format: Article
Language:English
Subjects:
Adult
Albuterol - therapeutic use
Asthma - physiopathology
Asthma, Exercise-Induced - blood
Asthma, Exercise-Induced - physiopathology
Asthma, Exercise-Induced - prevention & control
beta-Thromboglobulin - analysis
Biological and medical sciences
Blood Platelets - physiology
Cromolyn Sodium - therapeutic use
Humans
Medical sciences
Peak Expiratory Flow Rate
Pharmacology. Drug treatments
Platelet Factor 4 - analysis
Respiratory system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973
cites cdi_FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973
container_end_page 294
container_issue 4
container_start_page 290
container_title Thorax
container_volume 41
creator Johnson, C E
Belfield, P W
Davis, S
Cooke, N J
Spencer, A
Davies, J A
description Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma.
doi_str_mv 10.1136/thx.41.4.290
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_460312</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3974288771</sourcerecordid><originalsourceid>FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973</originalsourceid><addsrcrecordid>eNp9kc-PEyEcxYnRrN3Vm1cTEs16cSoMDAwmHkzj7826mtUrYQZoqcxQgVnb_142bRr14InD-3y_vO97ADzCaI4xYS_yajuneE7ntUB3wAxT1lakFuwumCFEUcUIZ_fBaUprhFCLMT8BJ7WgBFExA-srr7LxJkPVZ3ejsgsj1FN04xKarYm9Swa6UU-90VClvBrUS2isNX2GwcJNDJvVzqutS_CXyyvYxzCEpd_1ZStUo4ZJ-W7Kagj-AbhnlU_m4eE9A9_evrlevK8uPr_7sHh9UXUNanLVCIK1ReU0o2vKaoXrvtOYtHWDuw5rIQzmzDBhOsFaVltNiVBtZ23LBBecnIFX-72bqRuM7s2Yo_JyE92g4k4G5eTfyuhWchluJGWI4LrMnx_mY_g5mZTl4FJvvFejCVOSvHzDGkIK-OQfcB2mOJbbJOYcE0QEpoV6vqdKNClFY49OMJK3BcpSoKRYUlkKLPjjP90f4UNjRX960FXqlbdRjaWjI9ZyUqK7DaHaYy5lsz3KKv6QjBPeyMvvC_npmn79yK4u5ZfCP9vz3bD-v8HfgZ7Biw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771303914</pqid></control><display><type>article</type><title>Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol</title><source>Open Access: PubMed Central</source><creator>Johnson, C E ; Belfield, P W ; Davis, S ; Cooke, N J ; Spencer, A ; Davies, J A</creator><creatorcontrib>Johnson, C E ; Belfield, P W ; Davis, S ; Cooke, N J ; Spencer, A ; Davies, J A</creatorcontrib><description>Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.41.4.290</identifier><identifier>PMID: 2943049</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Adult ; Albuterol - therapeutic use ; Asthma - physiopathology ; Asthma, Exercise-Induced - blood ; Asthma, Exercise-Induced - physiopathology ; Asthma, Exercise-Induced - prevention &amp; control ; beta-Thromboglobulin - analysis ; Biological and medical sciences ; Blood Platelets - physiology ; Cromolyn Sodium - therapeutic use ; Humans ; Medical sciences ; Peak Expiratory Flow Rate ; Pharmacology. Drug treatments ; Platelet Factor 4 - analysis ; Respiratory system</subject><ispartof>Thorax, 1986-04, Vol.41 (4), p.290-294</ispartof><rights>1986 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Apr 1986</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973</citedby><cites>FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC460312/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC460312/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=8730117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2943049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, C E</creatorcontrib><creatorcontrib>Belfield, P W</creatorcontrib><creatorcontrib>Davis, S</creatorcontrib><creatorcontrib>Cooke, N J</creatorcontrib><creatorcontrib>Spencer, A</creatorcontrib><creatorcontrib>Davies, J A</creatorcontrib><title>Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol</title><title>Thorax</title><addtitle>Thorax</addtitle><description>Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma.</description><subject>Adult</subject><subject>Albuterol - therapeutic use</subject><subject>Asthma - physiopathology</subject><subject>Asthma, Exercise-Induced - blood</subject><subject>Asthma, Exercise-Induced - physiopathology</subject><subject>Asthma, Exercise-Induced - prevention &amp; control</subject><subject>beta-Thromboglobulin - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - physiology</subject><subject>Cromolyn Sodium - therapeutic use</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Peak Expiratory Flow Rate</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Factor 4 - analysis</subject><subject>Respiratory system</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNp9kc-PEyEcxYnRrN3Vm1cTEs16cSoMDAwmHkzj7826mtUrYQZoqcxQgVnb_142bRr14InD-3y_vO97ADzCaI4xYS_yajuneE7ntUB3wAxT1lakFuwumCFEUcUIZ_fBaUprhFCLMT8BJ7WgBFExA-srr7LxJkPVZ3ejsgsj1FN04xKarYm9Swa6UU-90VClvBrUS2isNX2GwcJNDJvVzqutS_CXyyvYxzCEpd_1ZStUo4ZJ-W7Kagj-AbhnlU_m4eE9A9_evrlevK8uPr_7sHh9UXUNanLVCIK1ReU0o2vKaoXrvtOYtHWDuw5rIQzmzDBhOsFaVltNiVBtZ23LBBecnIFX-72bqRuM7s2Yo_JyE92g4k4G5eTfyuhWchluJGWI4LrMnx_mY_g5mZTl4FJvvFejCVOSvHzDGkIK-OQfcB2mOJbbJOYcE0QEpoV6vqdKNClFY49OMJK3BcpSoKRYUlkKLPjjP90f4UNjRX960FXqlbdRjaWjI9ZyUqK7DaHaYy5lsz3KKv6QjBPeyMvvC_npmn79yK4u5ZfCP9vz3bD-v8HfgZ7Biw</recordid><startdate>19860401</startdate><enddate>19860401</enddate><creator>Johnson, C E</creator><creator>Belfield, P W</creator><creator>Davis, S</creator><creator>Cooke, N J</creator><creator>Spencer, A</creator><creator>Davies, J A</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860401</creationdate><title>Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol</title><author>Johnson, C E ; Belfield, P W ; Davis, S ; Cooke, N J ; Spencer, A ; Davies, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Albuterol - therapeutic use</topic><topic>Asthma - physiopathology</topic><topic>Asthma, Exercise-Induced - blood</topic><topic>Asthma, Exercise-Induced - physiopathology</topic><topic>Asthma, Exercise-Induced - prevention &amp; control</topic><topic>beta-Thromboglobulin - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - physiology</topic><topic>Cromolyn Sodium - therapeutic use</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Peak Expiratory Flow Rate</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Factor 4 - analysis</topic><topic>Respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, C E</creatorcontrib><creatorcontrib>Belfield, P W</creatorcontrib><creatorcontrib>Davis, S</creatorcontrib><creatorcontrib>Cooke, N J</creatorcontrib><creatorcontrib>Spencer, A</creatorcontrib><creatorcontrib>Davies, J A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, C E</au><au>Belfield, P W</au><au>Davis, S</au><au>Cooke, N J</au><au>Spencer, A</au><au>Davies, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1986-04-01</date><risdate>1986</risdate><volume>41</volume><issue>4</issue><spage>290</spage><epage>294</epage><pages>290-294</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>2943049</pmid><doi>10.1136/thx.41.4.290</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0040-6376
ispartof Thorax, 1986-04, Vol.41 (4), p.290-294
issn 0040-6376
1468-3296
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_460312
source Open Access: PubMed Central
subjects Adult
Albuterol - therapeutic use
Asthma - physiopathology
Asthma, Exercise-Induced - blood
Asthma, Exercise-Induced - physiopathology
Asthma, Exercise-Induced - prevention & control
beta-Thromboglobulin - analysis
Biological and medical sciences
Blood Platelets - physiology
Cromolyn Sodium - therapeutic use
Humans
Medical sciences
Peak Expiratory Flow Rate
Pharmacology. Drug treatments
Platelet Factor 4 - analysis
Respiratory system
title Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T18%3A42%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Platelet%20activation%20during%20exercise%20induced%20asthma:%20effect%20of%20prophylaxis%20with%20cromoglycate%20and%20salbutamol&rft.jtitle=Thorax&rft.au=Johnson,%20C%20E&rft.date=1986-04-01&rft.volume=41&rft.issue=4&rft.spage=290&rft.epage=294&rft.pages=290-294&rft.issn=0040-6376&rft.eissn=1468-3296&rft.coden=THORA7&rft_id=info:doi/10.1136/thx.41.4.290&rft_dat=%3Cproquest_pubme%3E3974288771%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b505t-5931df0113ed2462a12cbd138251bb1d99e176e69eb96862fd439a8bff8697973%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1771303914&rft_id=info:pmid/2943049&rfr_iscdi=true