Adiponectin is Not Associated With Blood Pressure in Normotensives and Untreated Hypertensives With Normal Kidney Function

The role of adiponectin in hypertension is still a matter of debate. Obtained conflicting results could be mostly explained with diversity of subjects included in different studies. Our aim was to analyze association of adiponectin with blood pressure (BP) in a group of normotensive and untreated hy...

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Bibliographic Details
Published in:Medicine (Baltimore) 2014-12, Vol.93 (28), p.e250-e250
Main Authors: Ivković, Vanja, Jelaković, Mislav, Laganović, Mario, Pećin, Ivan, Vrdoljak, Ana, Karanović, Sandra, Fuček, Mirjana, Božina, Tamara, Kos, Jelena, Željković Vrkić, Tajana, Premužić, Vedran, Živko, Marijana, Jelaković, Bojan
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Biomarkers - blood
Blood Pressure - physiology
Croatia - epidemiology
Cross-Sectional Studies
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hypertension - blood
Hypertension - epidemiology
Hypertension - physiopathology
Incidence
Kidney - physiology
Male
Middle Aged
Observational Study
Retrospective Studies
Risk Factors
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Summary:The role of adiponectin in hypertension is still a matter of debate. Obtained conflicting results could be mostly explained with diversity of subjects included in different studies. Our aim was to analyze association of adiponectin with blood pressure (BP) in a group of normotensive and untreated hypertensive subjects. Participants (N=257) were selected from a random sample of 2487 subjects enrolled in an observational cross-sectional study. Subjects with diabetes and chronic kidney diseases were excluded. BP was measured using Omron M6 device following ESH/ESC guidelines. Adiponectin concentration was determined by ELISA. There were no differences in adiponectin values (mg/L) between hypertensives and normotensives (median 9.75; iqr: 7.44-17.88 vs 11.35; iqr: 7.43-12.63; P=0.17). On univariate linear regression adiponectin was not associated with systolic or diastolic BP (P>0.05). Furthermore, multivariate analysis did not show significant contribution of log-transformed adiponectin either to systolic (β=-0.040; P=0.43) or diastolic BP (β=0.066; P=0.33). In our group of normotensives and untreated hypertensives with normal kidney function adiponectin was not associated with BP even after adjustment for other risk factors. Our results and conclusions should not be extrapolated to subjects with other characteristics.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000000250