Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

The physicochemical properties of nanoparticles (NPs) influence their biological outcomes. We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated an...

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Bibliographic Details
Published in:Particle and fibre toxicology 2015-10, Vol.12 (1), p.31, Article 31
Main Authors: Konduru, Nagarjun V, Jimenez, Renato J, Swami, Archana, Friend, Sherri, Castranova, Vincent, Demokritou, Philip, Brain, Joseph D, Molina, Ramon M
Format: Article
Language:English
Subjects:
Animals
Blood proteins
Cerium
Cerium - chemistry
Cerium oxides
Chemical properties
Coatings
Comparative analysis
Health aspects
Inflammation
Influence
Kinetics
Liver
Metal Nanoparticles
Microscopy, Electron
Nanomaterials
Nanoparticles
Nanotechnology
Oxidation
Oxidative stress
Particle size
Proteins
Pyrolysis
Rats
Silica
Silicon Dioxide - chemistry
Tissue Distribution
Toxicity
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Summary:The physicochemical properties of nanoparticles (NPs) influence their biological outcomes. We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection. Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more (141)Ce from silica-coated (35%) was cleared than from uncoated (19%) (141)CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary (141)Ce from silica-coated (141)CeO2 was still minimal (
ISSN:1743-8977
1743-8977
DOI:10.1186/s12989-015-0106-4