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Silica coating influences the corona and biokinetics of cerium oxide nanoparticles
The physicochemical properties of nanoparticles (NPs) influence their biological outcomes. We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated an...
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| Published in: | Particle and fibre toxicology 2015-10, Vol.12 (1), p.31, Article 31 |
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| creator | Konduru, Nagarjun V Jimenez, Renato J Swami, Archana Friend, Sherri Castranova, Vincent Demokritou, Philip Brain, Joseph D Molina, Ramon M |
| description | The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.
We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.
Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more (141)Ce from silica-coated (35%) was cleared than from uncoated (19%) (141)CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary (141)Ce from silica-coated (141)CeO2 was still minimal ( |
| doi_str_mv | 10.1186/s12989-015-0106-4 |
| format | article |
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We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.
Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more (141)Ce from silica-coated (35%) was cleared than from uncoated (19%) (141)CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary (141)Ce from silica-coated (141)CeO2 was still minimal (<1%) although lower than from uncoated (141)CeO2 NPs. Post-gavage, nearly 100% of both NPs were excreted in the feces consistent with very low gut absorption. Both IV-injected (141)CeO2 NP types were primarily retained in the liver and spleen. The silica coating significantly altered the plasma protein corona composition and enhanced retention of (141)Ce in other organs except the liver.
We conclude that silica coating of nanoceria alters the biodistribution of cerium likely due to modifications in protein corona formation after IT and IV administration.</description><identifier>ISSN: 1743-8977</identifier><identifier>EISSN: 1743-8977</identifier><identifier>DOI: 10.1186/s12989-015-0106-4</identifier><identifier>PMID: 26458946</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Blood proteins ; Cerium ; Cerium - chemistry ; Cerium oxides ; Chemical properties ; Coatings ; Comparative analysis ; Health aspects ; Inflammation ; Influence ; Kinetics ; Liver ; Metal Nanoparticles ; Microscopy, Electron ; Nanomaterials ; Nanoparticles ; Nanotechnology ; Oxidation ; Oxidative stress ; Particle size ; Proteins ; Pyrolysis ; Rats ; Silica ; Silicon Dioxide - chemistry ; Tissue Distribution ; Toxicity</subject><ispartof>Particle and fibre toxicology, 2015-10, Vol.12 (1), p.31, Article 31</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Konduru et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-f9c7904f43e191f4f97ad74ac962174e1310c2489a3d6fc750fb75d0b42356b93</citedby><cites>FETCH-LOGICAL-c528t-f9c7904f43e191f4f97ad74ac962174e1310c2489a3d6fc750fb75d0b42356b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603643/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1779734308?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,44588,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26458946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konduru, Nagarjun V</creatorcontrib><creatorcontrib>Jimenez, Renato J</creatorcontrib><creatorcontrib>Swami, Archana</creatorcontrib><creatorcontrib>Friend, Sherri</creatorcontrib><creatorcontrib>Castranova, Vincent</creatorcontrib><creatorcontrib>Demokritou, Philip</creatorcontrib><creatorcontrib>Brain, Joseph D</creatorcontrib><creatorcontrib>Molina, Ramon M</creatorcontrib><title>Silica coating influences the corona and biokinetics of cerium oxide nanoparticles</title><title>Particle and fibre toxicology</title><addtitle>Part Fibre Toxicol</addtitle><description>The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.
We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.
Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more (141)Ce from silica-coated (35%) was cleared than from uncoated (19%) (141)CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary (141)Ce from silica-coated (141)CeO2 was still minimal (<1%) although lower than from uncoated (141)CeO2 NPs. Post-gavage, nearly 100% of both NPs were excreted in the feces consistent with very low gut absorption. Both IV-injected (141)CeO2 NP types were primarily retained in the liver and spleen. The silica coating significantly altered the plasma protein corona composition and enhanced retention of (141)Ce in other organs except the liver.
We conclude that silica coating of nanoceria alters the biodistribution of cerium likely due to modifications in protein corona formation after IT and IV administration.</description><subject>Animals</subject><subject>Blood proteins</subject><subject>Cerium</subject><subject>Cerium - chemistry</subject><subject>Cerium oxides</subject><subject>Chemical properties</subject><subject>Coatings</subject><subject>Comparative analysis</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Influence</subject><subject>Kinetics</subject><subject>Liver</subject><subject>Metal Nanoparticles</subject><subject>Microscopy, Electron</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Particle size</subject><subject>Proteins</subject><subject>Pyrolysis</subject><subject>Rats</subject><subject>Silica</subject><subject>Silicon Dioxide - chemistry</subject><subject>Tissue Distribution</subject><subject>Toxicity</subject><issn>1743-8977</issn><issn>1743-8977</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptUl1LHTEQDaWlfrQ_oC8l0Kc-rE02X5sXQS5qBaGg7XPIZifX2N3kmuyK_fdGrrVeKGFImDnnMJk5CH2i5IjSTn4rtNWdbggVNYhs-Bu0TxVnTaeVevvqvYcOSrklhIlO0Pdor5VcdJrLfXR1HcbgLHbJziGucYh-XCA6KHi-gZrOKVps44D7kH6HCHNwBSePHeSwTDg9hAFwtDFtbK61EcoH9M7bscDH5_sQ_To7_bn63lz-OL9YnVw2TrTd3HjtlCbccwZUU8-9VnZQ3Dot29o4UEaJa3mnLRukd0oQ3ysxkJ63TMhes0N0vNXdLP0Eg4M4ZzuaTQ6TzX9MssHsVmK4Met0b7gkTHJWBb48C-R0t0CZzW1acqw9G6qUVowz0v1Dre0Ips4nVTE3heLMieBUsFa1pKKO_oOqZ4ApuBTBh5rfIXzdIVTMDA_z2i6lmIvrq10s3WJdTqVk8C-fpMQ8OcFsnWCqE8yTEwyvnM-vp_PC-Lt69gijra02</recordid><startdate>20151012</startdate><enddate>20151012</enddate><creator>Konduru, Nagarjun V</creator><creator>Jimenez, Renato J</creator><creator>Swami, Archana</creator><creator>Friend, 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Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konduru, Nagarjun V</au><au>Jimenez, Renato J</au><au>Swami, Archana</au><au>Friend, Sherri</au><au>Castranova, Vincent</au><au>Demokritou, Philip</au><au>Brain, Joseph D</au><au>Molina, Ramon M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silica coating influences the corona and biokinetics of cerium oxide nanoparticles</atitle><jtitle>Particle and fibre toxicology</jtitle><addtitle>Part Fibre Toxicol</addtitle><date>2015-10-12</date><risdate>2015</risdate><volume>12</volume><issue>1</issue><spage>31</spage><pages>31-</pages><artnum>31</artnum><issn>1743-8977</issn><eissn>1743-8977</eissn><abstract>The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.
We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.
Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more (141)Ce from silica-coated (35%) was cleared than from uncoated (19%) (141)CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary (141)Ce from silica-coated (141)CeO2 was still minimal (<1%) although lower than from uncoated (141)CeO2 NPs. Post-gavage, nearly 100% of both NPs were excreted in the feces consistent with very low gut absorption. Both IV-injected (141)CeO2 NP types were primarily retained in the liver and spleen. The silica coating significantly altered the plasma protein corona composition and enhanced retention of (141)Ce in other organs except the liver.
We conclude that silica coating of nanoceria alters the biodistribution of cerium likely due to modifications in protein corona formation after IT and IV administration.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26458946</pmid><doi>10.1186/s12989-015-0106-4</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Particle and fibre toxicology, 2015-10, Vol.12 (1), p.31, Article 31 |
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| source | Publicly Available Content Database; Full-Text Journals in Chemistry (Open access); PubMed Central |
| subjects | Animals Blood proteins Cerium Cerium - chemistry Cerium oxides Chemical properties Coatings Comparative analysis Health aspects Inflammation Influence Kinetics Liver Metal Nanoparticles Microscopy, Electron Nanomaterials Nanoparticles Nanotechnology Oxidation Oxidative stress Particle size Proteins Pyrolysis Rats Silica Silicon Dioxide - chemistry Tissue Distribution Toxicity |
| title | Silica coating influences the corona and biokinetics of cerium oxide nanoparticles |
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