Biogenesis and function of Porphyromonas gingivalis outer membrane vesicles

Porphyromonas gingivalis is one of the keystone pathogens associated with chronic periodontitis. All P. gingivalis strains examined thus far produce outer membrane vesicles. Recent studies have found that vesicles possess some well-known virulence factors of P. gingivalis such as adhesins, toxins an...

Full description

Saved in:
Bibliographic Details
Published in:Future microbiology 2015-09, Vol.10 (9), p.1517-1527
Main Author: Xie, H
Format: Article
Language:English
Subjects:
Adhesins
Adhesins, Bacterial - metabolism
Bacteria
Biofilms
Biosynthesis
E coli
Gram-negative bacteria
Gram-positive bacteria
Health aspects
Humans
Membrane vesicles
Microbial activity
Microbial Consortia - physiology
Microbiological research
Organelle Biogenesis
Pathogenicity
Pathogens
Periodontitis
Periodontitis - microbiology
Porphyromonas gingivalis
Porphyromonas gingivalis - cytology
Porphyromonas gingivalis - pathogenicity
Porphyromonas gingivalis - physiology
Porphyromonas gingivalis - ultrastructure
Proteins
Proteolysis
Proteolytic enzymes
Transmission electron microscopy
Transport Vesicles - physiology
Virulence (Microbiology)
Virulence factors
Virulence Factors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Porphyromonas gingivalis is one of the keystone pathogens associated with chronic periodontitis. All P. gingivalis strains examined thus far produce outer membrane vesicles. Recent studies have found that vesicles possess some well-known virulence factors of P. gingivalis such as adhesins, toxins and proteolytic enzymes. Carrying most of the characteristic features of their parent P. gingivalis cells, vesicles communicate with host cells and other members of microbial biofilms, resulting in the transmission of virulence factors into these host cells and the formation of pathogenic bacteria-dominated microbial communities. An in-depth understanding of both the nature and role of vesicles in the pathogenicity of P. gingivalis is both important and timely, particularly when speaking of periodontitis and its related systemic effects.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.15.63