Dissemination of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa in Romania

Fifteen carbapenemase-producing Enterobacteriaceae isolates and 12 carbapenemase-producing Pseudomonas aeruginosa isolates were recovered from patients hospitalized between August 2011 and March 2013 at the Hospital of Infectious Disease, Cluj-Napoca, Romania. One KPC-, nine NDM-1-, four OXA-48-, an...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2015-11, Vol.59 (11), p.7100-7103
Main Authors: Dortet, Laurent, Flonta, Mirela, Boudehen, Yves-Marie, Creton, Elodie, Bernabeu, Sandrine, Vogel, Anaïs, Naas, Thierry
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacterial Proteins
Bacterial Proteins - metabolism
beta-Lactamases
beta-Lactamases - metabolism
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - enzymology
Epidemiology and Surveillance
Plasmids - genetics
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - enzymology
Romania
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Summary:Fifteen carbapenemase-producing Enterobacteriaceae isolates and 12 carbapenemase-producing Pseudomonas aeruginosa isolates were recovered from patients hospitalized between August 2011 and March 2013 at the Hospital of Infectious Disease, Cluj-Napoca, Romania. One KPC-, nine NDM-1-, four OXA-48-, and one VIM-4-producing Enterobacteriaceae isolates along with 11 VIM-2-producing and one IMP-13-producing P. aeruginosa isolates were recovered from clinical samples. All carbapenemase genes were located on self-conjugative plasmids and were associated with other resistance determinants, including extended-spectrum β-lactamases and RmtC methylases.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01512-15