Impact of miRNAs on cardiovascular aging

Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs （miRNAs） have been shown to regulate gene expression, which contribu...

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Bibliographic Details
Published in:Journal of geriatric cardiology : JGC 2015-09, Vol.12 (5), p.569-574
Main Authors: Lee, Seahyoung, Choi, Eunhyun, Cha, Min-Ji, Park, Ae-Jun, Yoon, Cheesoon, Hwang, Ki-Chul
Format: Article
Language:English
Subjects:
miRNAs
Review
免疫性疾病
基因表达
心血管疾病
相关疾病
神经退行性疾病
细胞衰老
老化
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Summary:Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs （miRNAs） have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
ISSN:1671-5411
DOI:10.11909/j.issn.1671-5411.2015.05.011