Dysfunctional Default Mode Network in Methadone Treated Patients Who Have a Higher Heroin Relapse Risk

The purpose of this study was to identify whether heroin relapse is associated with changes in the functional connectivity of the default mode network (DMN) during methadone maintenance treatment (MMT). Resting-state functional magnetic resonance imaging (fMRI) data of chronic heroin relapsers (HR)...

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Published in:Scientific reports 2015-10, Vol.5 (1), p.15181, Article 15181
Main Authors: Li, Wei, Li, Qiang, Wang, Defeng, Xiao, Wei, Liu, Kai, Shi, Lin, Zhu, Jia, Li, Yongbin, Yan, Xuejiao, Chen, Jiajie, Ye, Jianjun, Li, Zhe, Wang, Yarong, Wang, Wei
Format: Article
Language:English
Subjects:
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692/617/375
Adult
Brain - diagnostic imaging
Brain - physiopathology
Brain Mapping
Cingulum
Cortex (parietal)
Female
Follow-Up Studies
Functional magnetic resonance imaging
Heroin
Heroin Dependence - drug therapy
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging
Male
Methadone
Methadone - therapeutic use
Middle Aged
multidisciplinary
Neural networks
Neural Pathways - physiopathology
Radiography
Recurrence
Risk
Science
Temporal gyrus
Temporal Lobe - diagnostic imaging
Temporal Lobe - physiopathology
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Summary:The purpose of this study was to identify whether heroin relapse is associated with changes in the functional connectivity of the default mode network (DMN) during methadone maintenance treatment (MMT). Resting-state functional magnetic resonance imaging (fMRI) data of chronic heroin relapsers (HR) (12 males, 1 female, age: 36.1 ± 6.9 years) and abstainers (HA) (11males, 2 female; age: 42.1 ± 8.1 years) were investigated with an independent component analysis to address the functional connectivity of their DMN. Group comparison was then performed between the relapsers and abstainers. Our study found that the left inferior temporal gyrus and the right superior occipital gyrus associated with DMN showed decreased functional connectivity in HR when compared with HA, while the left precuneus and the right middle cingulum had increased functional connectivity. Mean intensity signal, extracted from left inferior temporal gyrus of HR patients, showed a significant negative correlation corresponding to the degree of heroin relapse. These findings suggest that altered functional connectivity of DMN may contribute to the potential neurobiological mechanism(s) of heroin relapse and have a predictive value concerning heroin relapse under MMT.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep15181