Evaluating risk factors for Clostridiumdifficile infection in adult and pediatric hematopoietic cell transplant recipients

Background Although hematopoietic cell transplant (HCT) recipients are routinely exposed to classic risk factors for Clostridium difficile infection (CDI), few studies have assessed CDI risk in these high-risk patients, and data are especially lacking for pediatric HCT recipients. We aimed to determ...

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Bibliographic Details
Published in:Antimicrobial resistance & infection control 2015-10, Vol.4
Main Authors: Boyle, Nicole M, Magaret, Amalia, Stednick, Zach, Morrison, Alex, Butler-Wu, Susan, Zerr, Danielle, Rogers, Karin, Podczervinski, Sara, Cheng, Anqi, Wald, Anna, Pergam, Steven A
Format: Article
Language:English
Subjects:
Adults
Cancer
Complications and side effects
Diarrhea
Enzymes
Hematopoietic stem cells
Infection
Oncology, Experimental
Organ transplant recipients
Pediatrics
Risk factors
Transplantation
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Summary:Background Although hematopoietic cell transplant (HCT) recipients are routinely exposed to classic risk factors for Clostridium difficile infection (CDI), few studies have assessed CDI risk in these high-risk patients, and data are especially lacking for pediatric HCT recipients. We aimed to determine incidence and risk factors for CDI in adult and pediatric allogeneic HCT recipients. Methods CDI was defined as having diarrhea that tested positive for C. difficile via PCR, cytotoxin assay, or dual enzyme immunoassays. We included all patients who received an allogeneic HCT from 2008 to 2012 at the Fred Hutchinson Cancer Research Center; those
ISSN:2047-2994
2047-2994
DOI:10.1186/s13756-015-0081-4