Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis

Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often-protracted birth hospitalizations as they attain physiologic maturity. We examined the transcriptome using genome-wide expression profiling on prospec...

Full description

Saved in:
Bibliographic Details
Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2015-06, Vol.21 (1), p.496-504
Main Authors: Wynn, James L, Guthrie, Scott O, Wong, Hector R, Lahni, Patrick, Ungaro, Ricardo, Lopez, M Cecilia, Baker, Henry V, Moldawer, Lyle L
Format: Article
Language:English
Subjects:
Batch processing
Birth weight
Blood
Female
Gene expression
Gestational Age
Granulocytes
Humans
Infant
Infant, Newborn
Inflammation
Inflammation - blood
Inflammation - genetics
Inflammation - pathology
Laboratories
Male
Microarray Analysis
Pathophysiology
Patients
Pediatrics
Proteins
Risk Factors
Sepsis
Sepsis - blood
Sepsis - genetics
Sepsis - pathology
Transcriptome - genetics
Tumor necrosis factor-TNF
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often-protracted birth hospitalizations as they attain physiologic maturity. We examined the transcriptome using genome-wide expression profiling on prospectively collected peripheral blood samples from infants evaluated for sepsis within 24 h after clinical presentation. Simultaneous plasma samples were examined for alterations in inflammatory mediators. Group designation (sepsis or uninfected) was determined retrospectively on the basis of clinical exam and laboratory results over the next 72 h from the time of evaluation. Unsupervised analysis showed the major node of separation between groups was timing of sepsis episode relative to birth (early,
ISSN:1076-1551
1528-3658
DOI:10.2119/molmed.2015.00064