Selenium added unripe carica papaya pulp extracts enhance wound repair through TGF-β1 and VEGF-a signalling pathway

Increased wound healing efficiency by Se(2+) added Carica papaya L. (Caricaceae) fruit extract was linked to increased antioxidant and anti-inflammatory responses during healing. We investigated the impact of Se(2+) or Zn(2+) added papaya water (WE) and phosphate-buffered saline (PE) extracts on cel...

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Bibliographic Details
Published in:BMC complementary and alternative medicine 2015-10, Vol.15 (1), p.369-369, Article 369
Main Authors: Nafiu, Abdulrazaq Bidemi, Rahman, Mohammad Tariqur
Format: Article
Language:English
Subjects:
angiogenesis
Animals
antioxidants
Carica - chemistry
Carica papaya
collagen
Collagen - metabolism
complement
excision
fibroblasts
Fibroblasts - drug effects
Fibroblasts - metabolism
Fruit - chemistry
fruit extracts
Humans
Male
papayas
Plant Extracts - administration & dosage
protein content
pulp
Rats
Rats, Sprague-Dawley
selenium
Selenium - pharmacology
Signal Transduction - drug effects
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
Wound Healing - drug effects
Wounds and Injuries - drug therapy
Wounds and Injuries - genetics
Wounds and Injuries - metabolism
Wounds and Injuries - physiopathology
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Summary:Increased wound healing efficiency by Se(2+) added Carica papaya L. (Caricaceae) fruit extract was linked to increased antioxidant and anti-inflammatory responses during healing. We investigated the impact of Se(2+) or Zn(2+) added papaya water (WE) and phosphate-buffered saline (PE) extracts on cells recruitment and bio-molecular alterations on days 4 and 10 post wounding in an in vivo excision wound. Excision wounds were created on the dorsum of Sprague Dawley rats and treated topically twice/day with 20 μL of PE and WE (5 mg extract/mL), 0.5 μgSe(2+) added PE and WE (PES and WES), or 100 μMZn(2+) added PE and WE (PEZ and WEZ). Deionised water (negative) and Solcoseryl (positive) were applied on the control groups. Histochemical and biochemical assays were used to evaluate cellular and bio-molecular changes in the wound. PES (PE + 0.5 μg Se(2+)) only increased significantly (p 
ISSN:1472-6882
1472-6882
DOI:10.1186/s12906-015-0900-4