Use of bronchoalveolar lavage in the evaluation of methotrexate lung disease

The results of bronchoalveolar lavage in three patients with a presumptive diagnosis of methotrexate induced lung disease are presented. Lavage fluid was characterised by the presence of large numbers of lymphocytes, which in two patients were predominantly lymphocytes of the T8 phenotype. These fin...

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Bibliographic Details
Published in:Thorax 1987-09, Vol.42 (9), p.652-655
Main Authors: Akoun, G M, Mayaud, C M, Touboul, J L, Denis, M F, Milleron, B J, Perrot, J Y
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bronchoalveolar Lavage Fluid - pathology
Drug toxicity and drugs side effects treatment
Female
Humans
Leukocyte Count
Lung Diseases - chemically induced
Lung Diseases - pathology
Lymphocytes
Medical sciences
Methotrexate - adverse effects
Middle Aged
Neutrophils
Pharmacology. Drug treatments
Toxicity: respiratory system, ent, stomatology
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Summary:The results of bronchoalveolar lavage in three patients with a presumptive diagnosis of methotrexate induced lung disease are presented. Lavage fluid was characterised by the presence of large numbers of lymphocytes, which in two patients were predominantly lymphocytes of the T8 phenotype. These findings further support the hypothesis that immune mediated mechanisms may play a part in the pathogenesis of this disorder in some patients, and indicate that bronchoalveolar lavage may be helpful in the evaluation of patients suspected of having methotrexate induced lung disease.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.42.9.652