Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals

Objective. To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status. Methods. 503 AO patients without cardiovascular diseases were examined. Waist circumferen...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-9
Main Authors: Shlyakhto, E., Elena, Grineva, Bazhenova, E., Karonova, T., Baranova, E., Berkovich, O., Belyaeva, O., Berezina, A., Brovin, D.
Format: Article
Language:English
Subjects:
Adiponectin - genetics
Adult
Blood Glucose - metabolism
Blood Pressure
Body Mass Index
Cholesterol
Female
Genetic aspects
Humans
Insulin
Insulin - blood
Insulin resistance
Leptin - genetics
Lipids - blood
Male
Metabolic disorders
Middle Aged
Obesity
Obesity, Abdominal - epidemiology
Obesity, Abdominal - genetics
Obesity, Abdominal - metabolism
Obesity, Metabolically Benign - epidemiology
Obesity, Metabolically Benign - genetics
Obesity, Metabolically Benign - metabolism
Observations
Polymorphism, Single Nucleotide
Prevalence
Prevalence studies (Epidemiology)
Quantitative trait loci
Receptors, Leptin - genetics
Risk Factors
Russia - epidemiology
Statistics
Studies
Waist Circumference
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Summary:Objective. To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status. Methods. 503 AO patients without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose and serum insulin levels, HOMA-IR, lipid profile, and adiponectin (AN) and leptin (LEP) concentrations in serum were measured. Polymorphisms A19G and Q223R of the LEP and LEP receptor gene, and G276T and T45G of the AN gene were investigated. Results. 91.3% of patients were metabolically unhealthy obese (MUO), and 8.7% metabolically healthy obese (MHO). MHO patients were younger, and had lesser BMI and WC, while duration of obesity, frequency, and duration of physical training were greater than MUO patients p
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/548734