Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be e...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-9
Main Authors: Zhou, Tingyang, Zuo, Li, Chuang, Chia-Chen
Format: Article
Language:English
Subjects:
Antioxidants - metabolism
Antioxidants - therapeutic use
Apoptosis
Cardiomyocytes
Cardiovascular disease
Colleges & universities
Gangrene
Health aspects
Heart attacks
Humans
Injuries
Ischemia
Metabolism
Myocardial ischemia
Myocardial Ischemia - drug therapy
Myocardial Ischemia - metabolism
Myocardial Ischemia - physiopathology
Oxidative Stress
Oxygen
Physiological aspects
Physiology
Proteins
Reactive oxygen species
Reactive Oxygen Species - metabolism
Reperfusion injury
Reperfusion Injury - drug therapy
Reperfusion Injury - physiopathology
Review
Rodents
Signal Transduction
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Summary:Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue can result in further damage. Reactive oxygen species (ROS) have been studied intensively to reveal their role in myocardial I/R injury. Under normal conditions, ROS function as a mediator in many cell signaling pathways. However, stressful environments significantly induce the generation of ROS which causes the level to exceed body’s antioxidant defense system. Such altered redox homeostasis is implicated in myocardial I/R injury. Despite the detrimental effects from ROS, low levels of ROS have been shown to exert a protective effect in the ischemic preconditioning. In this review, we will summarize the detrimental role of ROS in myocardial I/R injury, the protective mechanism induced by ROS, and potential treatments for ROS-related myocardial injury.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/864946