Genetic and epigenetic changes associated with cholangiocarcinoma： From DNA methylation to microRNAs

Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an int...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2007-12, Vol.13 (48), p.6465-6469
Main Authors: Stutes, Monique, Tran, Steven, DeMorrow, Sharon
Format: Article
Language:English
Subjects:
Bile Duct Neoplasms - genetics
Bile Ducts, Intrahepatic
Cholangiocarcinoma - genetics
DNA Methylation
DNA, Neoplasm - genetics
Epigenesis, Genetic
Humans
MicroRNAs - genetics
Topic Highlight
催化剂
肿瘤抑制剂
胆管癌
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Description
Summary:Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations （by microRNA expression） and epigenetic changes （hypermethylation of specific gene promoters） that are thought to contribute to the carcinogenic process in cholancliocarcinoma.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v13.i48.6465