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Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs
Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an int...
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Published in: | World journal of gastroenterology : WJG 2007-12, Vol.13 (48), p.6465-6469 |
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container_title | World journal of gastroenterology : WJG |
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creator | Stutes, Monique Tran, Steven DeMorrow, Sharon |
description | Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations (by microRNA expression) and epigenetic changes (hypermethylation of specific gene promoters) that are thought to contribute to the carcinogenic process in cholancliocarcinoma. |
doi_str_mv | 10.3748/wjg.v13.i48.6465 |
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Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. 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subjects | Bile Duct Neoplasms - genetics Bile Ducts, Intrahepatic Cholangiocarcinoma - genetics DNA Methylation DNA, Neoplasm - genetics Epigenesis, Genetic Humans MicroRNAs - genetics Topic Highlight 催化剂 肿瘤抑制剂 胆管癌 |
title | Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs |
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