Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice

To study the relative efficacy of cisapride, metoclopramide, domperidone, erythromycin and mosapride on gastric emptying (GE) and small intestinal transit (SIT) in morphine treated mice. Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex. The groups include...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2003-04, Vol.9 (4), p.779-783
Main Authors: Suchitra, A D, Dkhar, S A, Shewade, D G, Shashindran, C H
Format: Article
Language:English
Subjects:
Animals
Basic Research
Benzamides - pharmacology
Cisapride - pharmacology
Domperidone - pharmacology
Drug Interactions
Erythromycin - pharmacology
Female
Gastric Emptying - drug effects
Gastric Emptying - physiology
Gastrointestinal Transit - drug effects
Gastrointestinal Transit - physiology
Male
Metoclopramide - pharmacology
Mice
Morphine - pharmacology
Morpholines - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study the relative efficacy of cisapride, metoclopramide, domperidone, erythromycin and mosapride on gastric emptying (GE) and small intestinal transit (SIT) in morphine treated mice. Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex. The groups included were control, morphine 1 mg/kg (s.c. 15 min before test meal) alone or with (45 min before test meal p.o.) cisapride 10 mg/kg, metoclopramide 20 mg/kg, domperidone 20 mg/kg, erythromycin 6 mg/kg and mosapride 20 mg/kg. Cisapride, metoclopramide and mosapride were effective in enhancing gastric emptying significantly (P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v9.i4.779