Efficacy of saccharomyces boulardii with antibiotics in acute amoebiasis

• Published in: World journal of gastroenterology : WJG 2003-08, Vol.9 (8), p.1832-1833
• Main Authors: Mansour-Ghanaei, Fariborz, Dehbashi, Najaf, Yazdanparast, Kamyar, Shafaghi, Afshin
• Format: Article
• Language: English
• Subjects: Acute Disease; Administration, Oral; Amebiasis - therapy; Amebicides - therapeutic use; Anti-Bacterial Agents; Anti-Infective Agents - therapeutic use; Brief Reports; Capsules; Double-Blind Method; Drug Therapy, Combination - therapeutic use; Humans; Iodoquinol - therapeutic use; Metronidazole - therapeutic use; Probiotics - administration & dosage; Saccharomyces; Treatment Outcome; 临床疗效; 抗生素; 阿米巴病
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v9.i8.1832

AIM: To compare the efficacy of antibiotics therapy alone with antibiotics and saccharomyces boulardii in treatment of acute amebiasis.METHODS: In a double blind, random clinical trial on patients with acute intestinal amoebiasis, 57 adult patients with acute amoebiasis, diagnosed with dinical manifestations (acute mucous bloody diarrhea) and amebic trophozoites engulfing RBCs found in stool were enrolled in the study.Regimen 1 induded mebonidazole (750mg Tid) and iodoquinol(630 mg Tid) for 10 days. Regimen 2 contained capsules of lyophilized saccharomyces boulardii (250 mg Tid) orally in addition to regimen 1. Patients were re-examined at two and four weeks after the treatment, and stool examination was performed at the end of week 4. Student's t-test, X^2 and McNemar's tests were used for statistical analysis.RESULTS: Three patients refused to participate. The other 54 patients were randomized to receive either regimen 1 or regimen 2 (Groups 1 and 2 respectively, each with 27 patients). The two groups were similar regarding their age,sex and clinical manifestations. In Group 1, diarrhea lasted 48.0±18.5 hours and in Group 2, 12.0±3.7 hours (P