Prazosin in the treatment of chronic asthma

The role of prazosin, an alpha 1 adrenoceptor blocker, was investigated in patients with chronic stable asthma who continued to have symptoms despite conventional treatment. Forty patients were entered into a double blind, placebo controlled, crossover trial to examine the effect of adding oral praz...

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Bibliographic Details
Published in:Thorax 1988-05, Vol.43 (5), p.385-387
Main Authors: Baudouin, S V, Aitman, T J, Johnson, A J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Asthma - drug therapy
Asthma - physiopathology
Biological and medical sciences
Clinical Trials as Topic
Double-Blind Method
Female
Forced Expiratory Volume
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prazosin - adverse effects
Prazosin - therapeutic use
Respiratory system
Vital Capacity
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Summary:The role of prazosin, an alpha 1 adrenoceptor blocker, was investigated in patients with chronic stable asthma who continued to have symptoms despite conventional treatment. Forty patients were entered into a double blind, placebo controlled, crossover trial to examine the effect of adding oral prazosin (2 mg twice daily) to previous medication for three weeks. Sixteen patients withdrew from the study. The remaining 24 patients showed no significant change in peak expiratory flow, FEV1, forced vital capacity (FVC), FEV1/FVC ratio, diary card symptom scores, or dose of beta sympathomimetic.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.43.5.385