New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix

Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison,...

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Published in:International journal of molecular sciences 2015-09, Vol.16 (9), p.21950-21958
Main Authors: Lai, Ya-Yuan, Chen, Li-Chai, Wu, Chug-Fung, Lu, Mei-Chin, Wen, Zhi-Hong, Wu, Tung-Ying, Fang, Lee-Shing, Wang, Li-Hsueh, Wu, Yang-Chang, Sung, Ping-Jyun
Format: Article
Language:English
Subjects:
Animals
Aquatic life
Cell Line
Cell Proliferation - drug effects
Cytotoxicity
Humans
Ircinia felix
Marine ecology
Molecular Structure
Porifera - chemistry
Sesterterpenes - chemistry
Sesterterpenes - toxicity
Studies
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Summary:Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 μM).
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms160921950