Resveratrol prolongs allograft survival after liver transplantation in rats

• Published in: World journal of gastroenterology : WJG 2005-08, Vol.11 (30), p.4745-4749
• Main Authors: Wu, Sheng-Li, Yu, Liang, Meng, Ke-Wei, Ma, Zhen-Hua, Pan, Cheng-En
• Format: Article
• Language: English
• Subjects: Animals; Brief Reports; Graft Survival - drug effects; Immunosuppressive Agents - pharmacology; Liver Transplantation - immunology; Liver Transplantation - pathology; Liver Transplantation - physiology; Male; NF-kappa B - metabolism; Rats; Rats, Sprague-Dawley; Rats, Wistar; Resveratrol; Stilbenes - pharmacology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Transplantation, Homologous; 动物实验; 同种异体移植物; 组织病理学; 肝移植
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i30.4745

AIM： To study the immuno-modulatory effect of resveratrol （RES） on allograft rejection after liver transplantation in rats. METHODS： Male Sprague-Dawley （SD） rats were selected as donors and male Wistar rats as recipients for a rejection model. The recipients were divided into four groups after orthotopic liver transplantation （OLTx）. In the RES A, B, and C groups, RES was given intra-peritoneally once a day （25, 50, and 100 mg/kg, respectively） after OLTx, whereas in the control group, vehicle buffer was given intra-peritoneally once a day. The survival time, serum chemistry, production of cytokines, activation of transcription factor NF-kB, and histopathologic findings were then compared among these groups. RESULTS： The mean survival time after OLTx in the RES C group was significantly longer than that in the control group （16.7＋-1.2 d ,vs9.3＋-0.6 d, P〈0.01）. On the 7th posttransplant day the serum albumin level significantly improved in the RES C group, the serum total bile acid and alanine aminotransferase （ALT） levels were significantly lower in the RES C group, the serum IL-2 and INF-y levels were significantly lower in the RES C group, and the activation of transcription factor NF-kB in peripheral blood T lymphocytes was significantly suppressed in the RES A, B, and C groups in comparison to those in the control group. On the 7^th post-transplant day, a histological examination revealed apparent difference in the severity of rejection between the RES C group and control group. CONCLUSION： RES has an immuno-suppressive property as well as protective effect on hepatocytes under allograft rejection. It might serve as a novel agent for reducing the severity of hepatic allograft rejection in rats.