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Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study
Purpose To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. Methods HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over mult...
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Published in: | Quality of life research 2015-12, Vol.24 (12), p.2895-2906 |
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creator | Holtzer-Goor, K. M. Schaafsma, M. R. Joosten, P. Posthuma, E. F. M. Wittebol, S. Huijgens, P. C. Mattijssen, E. J. M. Vreugdenhil, G. Visser, H. Peters, W. G. Erjavec, Z. Wijermans, P. W. Daenen, S. M. G. J. van der Hem, K. G. van Oers, M. H. J. Uyl-de Groot, C. A. |
description | Purpose To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. Methods HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any active treatment ("watch and wait"), chlorambucil treatment only, and patients with other treatment(s). Results HRQoL in the total group of CLL patients was compromised when compared with age- and gender-matched norm scores of the general population. CLL patients scored statistically worse on the VAS and utility score of the EQ-5D, all functioning scales of the EORTC QLQ-C30, and the symptoms of fatigue, dyspnoea, sleeping disturbance, appetite loss, and financial difficulties. In untreated patients, the HRQoL was slightly reduced. In all treatment stages, HRQoL was compromised considerably. Patients treated with chlorambucil only scored worse on the EORTC QLQ-C30 than patients who were treated with other treatments with regard to emotional functioning, cognitive functioning, bruises, uncomfortable stomach, and apathy. Conclusions CLL patients differ most from the general population on role functioning, fatigue, concerns about future health, and having not enough energy. Once treatment is indicated, HRQoL becomes considerably compromised. This applies to all treatments, including chlorambucil, which is considered to be a mild treatment. |
doi_str_mv | 10.1007/s11136-015-1039-y |
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M. ; Schaafsma, M. R. ; Joosten, P. ; Posthuma, E. F. M. ; Wittebol, S. ; Huijgens, P. C. ; Mattijssen, E. J. M. ; Vreugdenhil, G. ; Visser, H. ; Peters, W. G. ; Erjavec, Z. ; Wijermans, P. W. ; Daenen, S. M. G. J. ; van der Hem, K. G. ; van Oers, M. H. J. ; Uyl-de Groot, C. A.</creator><creatorcontrib>Holtzer-Goor, K. M. ; Schaafsma, M. R. ; Joosten, P. ; Posthuma, E. F. M. ; Wittebol, S. ; Huijgens, P. C. ; Mattijssen, E. J. M. ; Vreugdenhil, G. ; Visser, H. ; Peters, W. G. ; Erjavec, Z. ; Wijermans, P. W. ; Daenen, S. M. G. J. ; van der Hem, K. G. ; van Oers, M. H. J. ; Uyl-de Groot, C. A.</creatorcontrib><description>Purpose To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. Methods HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any active treatment ("watch and wait"), chlorambucil treatment only, and patients with other treatment(s). Results HRQoL in the total group of CLL patients was compromised when compared with age- and gender-matched norm scores of the general population. CLL patients scored statistically worse on the VAS and utility score of the EQ-5D, all functioning scales of the EORTC QLQ-C30, and the symptoms of fatigue, dyspnoea, sleeping disturbance, appetite loss, and financial difficulties. In untreated patients, the HRQoL was slightly reduced. In all treatment stages, HRQoL was compromised considerably. Patients treated with chlorambucil only scored worse on the EORTC QLQ-C30 than patients who were treated with other treatments with regard to emotional functioning, cognitive functioning, bruises, uncomfortable stomach, and apathy. Conclusions CLL patients differ most from the general population on role functioning, fatigue, concerns about future health, and having not enough energy. Once treatment is indicated, HRQoL becomes considerably compromised. This applies to all treatments, including chlorambucil, which is considered to be a mild treatment.</description><identifier>ISSN: 0962-9343</identifier><identifier>EISSN: 1573-2649</identifier><identifier>DOI: 10.1007/s11136-015-1039-y</identifier><identifier>PMID: 26205768</identifier><language>eng</language><publisher>Cham: Springer</publisher><subject>Adult ; Aged ; Cancer therapies ; Chlorambucil - adverse effects ; Chlorambucil - therapeutic use ; Chronic illnesses ; CLINICAL AND POLICY APPLICATIONS ; Clinical trials ; Dyspnea ; Dyspnea - psychology ; Fatigue - psychology ; Female ; Health Status ; Humans ; Leukemia ; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell - psychology ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Netherlands ; Observational studies ; Patients ; Population ; Public Health ; Quality of Life ; Quality of Life Research ; Questionnaires ; Sleep Wake Disorders - psychology ; Sociology ; Surveys and Questionnaires</subject><ispartof>Quality of life research, 2015-12, Vol.24 (12), p.2895-2906</ispartof><rights>Springer International Publishing 2015</rights><rights>The Author(s) 2015</rights><rights>Springer International Publishing Switzerland 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-b48617034b63a4aa8d697667e05c0dda717aa04f35f70f49f512d9389facfcb43</citedby><cites>FETCH-LOGICAL-c525t-b48617034b63a4aa8d697667e05c0dda717aa04f35f70f49f512d9389facfcb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1725380263/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1725380263?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,11688,27924,27925,36060,36061,44363,58238,58471,74895</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26205768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holtzer-Goor, K. M.</creatorcontrib><creatorcontrib>Schaafsma, M. R.</creatorcontrib><creatorcontrib>Joosten, P.</creatorcontrib><creatorcontrib>Posthuma, E. F. M.</creatorcontrib><creatorcontrib>Wittebol, S.</creatorcontrib><creatorcontrib>Huijgens, P. C.</creatorcontrib><creatorcontrib>Mattijssen, E. J. M.</creatorcontrib><creatorcontrib>Vreugdenhil, G.</creatorcontrib><creatorcontrib>Visser, H.</creatorcontrib><creatorcontrib>Peters, W. G.</creatorcontrib><creatorcontrib>Erjavec, Z.</creatorcontrib><creatorcontrib>Wijermans, P. W.</creatorcontrib><creatorcontrib>Daenen, S. M. G. J.</creatorcontrib><creatorcontrib>van der Hem, K. G.</creatorcontrib><creatorcontrib>van Oers, M. H. J.</creatorcontrib><creatorcontrib>Uyl-de Groot, C. A.</creatorcontrib><title>Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study</title><title>Quality of life research</title><addtitle>Qual Life Res</addtitle><addtitle>Qual Life Res</addtitle><description>Purpose To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. Methods HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any active treatment ("watch and wait"), chlorambucil treatment only, and patients with other treatment(s). Results HRQoL in the total group of CLL patients was compromised when compared with age- and gender-matched norm scores of the general population. CLL patients scored statistically worse on the VAS and utility score of the EQ-5D, all functioning scales of the EORTC QLQ-C30, and the symptoms of fatigue, dyspnoea, sleeping disturbance, appetite loss, and financial difficulties. In untreated patients, the HRQoL was slightly reduced. In all treatment stages, HRQoL was compromised considerably. Patients treated with chlorambucil only scored worse on the EORTC QLQ-C30 than patients who were treated with other treatments with regard to emotional functioning, cognitive functioning, bruises, uncomfortable stomach, and apathy. Conclusions CLL patients differ most from the general population on role functioning, fatigue, concerns about future health, and having not enough energy. Once treatment is indicated, HRQoL becomes considerably compromised. This applies to all treatments, including chlorambucil, which is considered to be a mild treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer therapies</subject><subject>Chlorambucil - adverse effects</subject><subject>Chlorambucil - therapeutic use</subject><subject>Chronic illnesses</subject><subject>CLINICAL AND POLICY APPLICATIONS</subject><subject>Clinical trials</subject><subject>Dyspnea</subject><subject>Dyspnea - psychology</subject><subject>Fatigue - psychology</subject><subject>Female</subject><subject>Health Status</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - psychology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Population</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Quality of Life Research</subject><subject>Questionnaires</subject><subject>Sleep Wake Disorders - psychology</subject><subject>Sociology</subject><subject>Surveys and Questionnaires</subject><issn>0962-9343</issn><issn>1573-2649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNqNkk2PFCEQhjtG446rP8CDhsSLl1a-aTyYmI1fyUZjomfC0DDDSDcj0Jq--Nult9fJ6sF4oUjx1kMVvE3zEMFnCELxPCOECG8hYi2CRLbzrWaDmCAt5lTebjZQctxKQslZcy_nA4SwkxDfbc4wx5AJ3m2an58mHXyZQXQgeGeXeNTF27Fk8MOXPTD7FEdvQJiH4z6auSx7O33VdvAa-BGUvQUfbF1T0GOfX4Bk8xRqeUVpEOK482Xq_agDGGrem8pOFuSanO83d5wO2T64jufNlzevP1-8ay8_vn1_8eqyNQyz0m5px5GAhG450VTrrudScC4sZAb2vRZIaA2pI8wJ6Kh0DOFekk46bZzZUnLevFy5x2k72P6qBR3UMflBp1lF7dWfJ6Pfq138rihHjHNUAU-vASl-m2wuavDZ2FBHtnHKCgnKu45Dxv9DigUljIiF-uQv6SFOqb7UlYqRDmJOqgqtKpNizsm6U98IqsUIajWCqkZQixHUXGse3xz4VPH756sAr4Jcj8adTTeu_gf10Vp0yCWmE5TSjkoiKfkFxkPK7w</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Holtzer-Goor, K. 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M.</au><au>Schaafsma, M. R.</au><au>Joosten, P.</au><au>Posthuma, E. F. M.</au><au>Wittebol, S.</au><au>Huijgens, P. C.</au><au>Mattijssen, E. J. M.</au><au>Vreugdenhil, G.</au><au>Visser, H.</au><au>Peters, W. G.</au><au>Erjavec, Z.</au><au>Wijermans, P. W.</au><au>Daenen, S. M. G. J.</au><au>van der Hem, K. G.</au><au>van Oers, M. H. J.</au><au>Uyl-de Groot, C. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study</atitle><jtitle>Quality of life research</jtitle><stitle>Qual Life Res</stitle><addtitle>Qual Life Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>24</volume><issue>12</issue><spage>2895</spage><epage>2906</epage><pages>2895-2906</pages><issn>0962-9343</issn><eissn>1573-2649</eissn><abstract>Purpose To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. Methods HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any active treatment ("watch and wait"), chlorambucil treatment only, and patients with other treatment(s). Results HRQoL in the total group of CLL patients was compromised when compared with age- and gender-matched norm scores of the general population. CLL patients scored statistically worse on the VAS and utility score of the EQ-5D, all functioning scales of the EORTC QLQ-C30, and the symptoms of fatigue, dyspnoea, sleeping disturbance, appetite loss, and financial difficulties. In untreated patients, the HRQoL was slightly reduced. In all treatment stages, HRQoL was compromised considerably. Patients treated with chlorambucil only scored worse on the EORTC QLQ-C30 than patients who were treated with other treatments with regard to emotional functioning, cognitive functioning, bruises, uncomfortable stomach, and apathy. Conclusions CLL patients differ most from the general population on role functioning, fatigue, concerns about future health, and having not enough energy. Once treatment is indicated, HRQoL becomes considerably compromised. This applies to all treatments, including chlorambucil, which is considered to be a mild treatment.</abstract><cop>Cham</cop><pub>Springer</pub><pmid>26205768</pmid><doi>10.1007/s11136-015-1039-y</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Cancer therapies Chlorambucil - adverse effects Chlorambucil - therapeutic use Chronic illnesses CLINICAL AND POLICY APPLICATIONS Clinical trials Dyspnea Dyspnea - psychology Fatigue - psychology Female Health Status Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - psychology Longitudinal Studies Male Medicine Medicine & Public Health Middle Aged Netherlands Observational studies Patients Population Public Health Quality of Life Quality of Life Research Questionnaires Sleep Wake Disorders - psychology Sociology Surveys and Questionnaires |
title | Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study |
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