Clinicopathological Characteristics and Survival Outcomes of Invasive Cribriform Carcinoma of Breast: A SEER Population-Based Study

Invasive cribriform carcinoma (ICC) is a rare histologic subtype of breast cancer. We aimed to investigate the clinicopathological characteristics and survival outcomes of ICC.Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 233,337 female patients diagnosed with...

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Bibliographic Details
Published in:Medicine (Baltimore) 2015-08, Vol.94 (31), p.e1309-e1309
Main Authors: Liu, Xi-Yu, Jiang, Yi-Zhou, Liu, Yi-Rong, Zuo, Wen-Jia, Shao, Zhi-Ming
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Adult
Aged
Aged, 80 and over
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Observational Study
Retrospective Studies
SEER Program
Socioeconomic Factors
Survival Rate
United States - epidemiology
Young Adult
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Summary:Invasive cribriform carcinoma (ICC) is a rare histologic subtype of breast cancer. We aimed to investigate the clinicopathological characteristics and survival outcomes of ICC.Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 233,337 female patients diagnosed with ICC (n = 618) or infiltrating ductal carcinoma (IDC) (n = 232,719). Univariate and multivariate survival analyses were utilized to calculate and compare disease-specific survival (DSS) and overall survival (OS). A 1:1 paired match was carried out on age, tumor stage, tumor grade, estrogen receptor (ER) status, and progesterone receptor (PR) status. Baseline characteristics and survival outcomes were also analyzed in ER-positive tumors. Subgroup analyses summarized the hazard ratio (HR) of IDC versus ICC using a forest plot.ICCs presented smaller size, lower grade, higher ER and PR positive rate, less nodal metastasis, and were less likely to be treated with mastectomy compared to IDCs. Five-year DSS rates were significantly better for patients with ICC than for patients with IDC (98.8% vs. 93%, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000001309