Loading…

Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis

Tenascin (TN) is an extracellular oligomeric glycoprotein that participates in the adhesion of cells to extracellular matrixc (ECM). Studies have shown that the expression levels of TN are upregulated in a variety of cancers, including colon cancer, lung cancer, brain tumor, and breast cancer. Howev...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2015-08, Vol.94 (32), p.e1330-e1330
Main Authors: Kong, Xiangyi, Ma, Wenbin, Li, Yongning, Wang, Yu, Guan, Jian, Gao, Jun, Wei, Junji, Yao, Yong, Lian, Wei, Xu, Zhiqin, Dou, Wanchen, Xing, Bing, Ren, Zuyuan, Su, Changbao, Yang, Yi, Wang, Renzhi
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c3557-cdb6c60439f5a15a7a519937970369154edbe790e052e0cc1315fb0d8880e8413
container_end_page e1330
container_issue 32
container_start_page e1330
container_title Medicine (Baltimore)
container_volume 94
creator Kong, Xiangyi
Ma, Wenbin
Li, Yongning
Wang, Yu
Guan, Jian
Gao, Jun
Wei, Junji
Yao, Yong
Lian, Wei
Xu, Zhiqin
Dou, Wanchen
Xing, Bing
Ren, Zuyuan
Su, Changbao
Yang, Yi
Wang, Renzhi
description Tenascin (TN) is an extracellular oligomeric glycoprotein that participates in the adhesion of cells to extracellular matrixc (ECM). Studies have shown that the expression levels of TN are upregulated in a variety of cancers, including colon cancer, lung cancer, brain tumor, and breast cancer. However, the implications and utilities of TN in clinical grading and prognosis of glioma patients were seldom reported and the effects of its pathway are still unclear and controversial. Thus, it is essential to carry out a meta-analysis to draw a convincing conclusion.A literature search was carried out up to April 2015. Data was collected using a purpose-designed form including glioma's WHO grade, etc. Differences were expressed as odds ratios (ORs) or standard mean differences (SMDs) with 95% confidence intervals (CIs). Galbr figure, Cochran's Q test, and I test were all performed to judge the heterogeneity between included studies. To examine the stability of the pooled results, a sensitivity analysis was performed. Potential publication bias was assessed by visual inspection of funnel plot. As this meta-analysis, as a systematic review, does not involve animal experiments or direct human trials, there is no need to conduct special ethic review and the ethical approval is not necessary.In this meta-analysis, 8 eligible studies involving 456 patients were incorporated. Six studies with dichotomous data revealed TN overexpression in glioma tissues and/or surrounding neoplastic vessels was closely associated with high WHO grade (III + IV) (odds ratio 3.398, 95% confidence interval 1.933, 5.974; P = 0.000); three continuous data studies showed there were close statistical associations between TN and WHO grade (SMD -2.114, 95% CI -2.580, -1.649; P = 0.000) too. Sensitivity analysis indicated a statistically robust result. No publication bias was revealed.Our meta-analysis suggests that TN expression is potentially associated with higher WHO grade of gliomas. More evidences on the basis of the evidence-based medicine are needed to prove it.
doi_str_mv 10.1097/MD.0000000000001330
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4616677</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1704349946</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3557-cdb6c60439f5a15a7a519937970369154edbe790e052e0cc1315fb0d8880e8413</originalsourceid><addsrcrecordid>eNpdUV1vEzEQtBCIhsIvQEJ-5OVa-_x15gEUJTRUagQS5dlyfHs9g-8c7Eur_HucplQFv6y1Mzs7q0HoLSVnlGh1vl6ekSePMkaeoRkVTFZCS_4czQipRaW04ifoVc4_DxxV85fopJa1lEypGRqXETK-htFm50fc21vAi-BH72zAl8M2lM_k45hxQb_ZqY8h3tyDq2RbwLHDq-DjYA-gh3HKnz7gOf6-zxMMpePwGiZbzUcb9tnn1-hFZ0OGNw_1FP24-Hy9-FJdfV1dLuZXlWNCqMq1G-kk4Ux3wlJhlRVUa1ZOIUxqKji0G1CaABE1EOcoo6LbkLZpGgINp-wUfTzqbnebAVpXjCUbzDb5waa9idabf5HR9-Ym3houqZRKFYH3DwIp_t5Bnszgs4MQ7Ahxlw1VxR3XmstCZUeqSzHnBN3jGkrMISmzXpr_kypT7546fJz5G00h8CPhLoYJUv4VdneQTA82TP29nlC6rmpCBWlITarSYYr9AXpMnl0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1704349946</pqid></control><display><type>article</type><title>Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis</title><source>LWW_医学期刊</source><source>IngentaConnect Journals</source><source>PubMed Central</source><creator>Kong, Xiangyi ; Ma, Wenbin ; Li, Yongning ; Wang, Yu ; Guan, Jian ; Gao, Jun ; Wei, Junji ; Yao, Yong ; Lian, Wei ; Xu, Zhiqin ; Dou, Wanchen ; Xing, Bing ; Ren, Zuyuan ; Su, Changbao ; Yang, Yi ; Wang, Renzhi</creator><creatorcontrib>Kong, Xiangyi ; Ma, Wenbin ; Li, Yongning ; Wang, Yu ; Guan, Jian ; Gao, Jun ; Wei, Junji ; Yao, Yong ; Lian, Wei ; Xu, Zhiqin ; Dou, Wanchen ; Xing, Bing ; Ren, Zuyuan ; Su, Changbao ; Yang, Yi ; Wang, Renzhi</creatorcontrib><description>Tenascin (TN) is an extracellular oligomeric glycoprotein that participates in the adhesion of cells to extracellular matrixc (ECM). Studies have shown that the expression levels of TN are upregulated in a variety of cancers, including colon cancer, lung cancer, brain tumor, and breast cancer. However, the implications and utilities of TN in clinical grading and prognosis of glioma patients were seldom reported and the effects of its pathway are still unclear and controversial. Thus, it is essential to carry out a meta-analysis to draw a convincing conclusion.A literature search was carried out up to April 2015. Data was collected using a purpose-designed form including glioma's WHO grade, etc. Differences were expressed as odds ratios (ORs) or standard mean differences (SMDs) with 95% confidence intervals (CIs). Galbr figure, Cochran's Q test, and I test were all performed to judge the heterogeneity between included studies. To examine the stability of the pooled results, a sensitivity analysis was performed. Potential publication bias was assessed by visual inspection of funnel plot. As this meta-analysis, as a systematic review, does not involve animal experiments or direct human trials, there is no need to conduct special ethic review and the ethical approval is not necessary.In this meta-analysis, 8 eligible studies involving 456 patients were incorporated. Six studies with dichotomous data revealed TN overexpression in glioma tissues and/or surrounding neoplastic vessels was closely associated with high WHO grade (III + IV) (odds ratio 3.398, 95% confidence interval 1.933, 5.974; P = 0.000); three continuous data studies showed there were close statistical associations between TN and WHO grade (SMD -2.114, 95% CI -2.580, -1.649; P = 0.000) too. Sensitivity analysis indicated a statistically robust result. No publication bias was revealed.Our meta-analysis suggests that TN expression is potentially associated with higher WHO grade of gliomas. More evidences on the basis of the evidence-based medicine are needed to prove it.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000001330</identifier><identifier>PMID: 26266377</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Brain Neoplasms - pathology ; Glioma - pathology ; Humans ; Neoplasm Grading ; Prognosis ; Systematic Review and Meta-Analysis ; Tenascin - biosynthesis</subject><ispartof>Medicine (Baltimore), 2015-08, Vol.94 (32), p.e1330-e1330</ispartof><rights>Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3557-cdb6c60439f5a15a7a519937970369154edbe790e052e0cc1315fb0d8880e8413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616677/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616677/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26266377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Xiangyi</creatorcontrib><creatorcontrib>Ma, Wenbin</creatorcontrib><creatorcontrib>Li, Yongning</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Guan, Jian</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Wei, Junji</creatorcontrib><creatorcontrib>Yao, Yong</creatorcontrib><creatorcontrib>Lian, Wei</creatorcontrib><creatorcontrib>Xu, Zhiqin</creatorcontrib><creatorcontrib>Dou, Wanchen</creatorcontrib><creatorcontrib>Xing, Bing</creatorcontrib><creatorcontrib>Ren, Zuyuan</creatorcontrib><creatorcontrib>Su, Changbao</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Wang, Renzhi</creatorcontrib><title>Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Tenascin (TN) is an extracellular oligomeric glycoprotein that participates in the adhesion of cells to extracellular matrixc (ECM). Studies have shown that the expression levels of TN are upregulated in a variety of cancers, including colon cancer, lung cancer, brain tumor, and breast cancer. However, the implications and utilities of TN in clinical grading and prognosis of glioma patients were seldom reported and the effects of its pathway are still unclear and controversial. Thus, it is essential to carry out a meta-analysis to draw a convincing conclusion.A literature search was carried out up to April 2015. Data was collected using a purpose-designed form including glioma's WHO grade, etc. Differences were expressed as odds ratios (ORs) or standard mean differences (SMDs) with 95% confidence intervals (CIs). Galbr figure, Cochran's Q test, and I test were all performed to judge the heterogeneity between included studies. To examine the stability of the pooled results, a sensitivity analysis was performed. Potential publication bias was assessed by visual inspection of funnel plot. As this meta-analysis, as a systematic review, does not involve animal experiments or direct human trials, there is no need to conduct special ethic review and the ethical approval is not necessary.In this meta-analysis, 8 eligible studies involving 456 patients were incorporated. Six studies with dichotomous data revealed TN overexpression in glioma tissues and/or surrounding neoplastic vessels was closely associated with high WHO grade (III + IV) (odds ratio 3.398, 95% confidence interval 1.933, 5.974; P = 0.000); three continuous data studies showed there were close statistical associations between TN and WHO grade (SMD -2.114, 95% CI -2.580, -1.649; P = 0.000) too. Sensitivity analysis indicated a statistically robust result. No publication bias was revealed.Our meta-analysis suggests that TN expression is potentially associated with higher WHO grade of gliomas. More evidences on the basis of the evidence-based medicine are needed to prove it.</description><subject>Brain Neoplasms - pathology</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Neoplasm Grading</subject><subject>Prognosis</subject><subject>Systematic Review and Meta-Analysis</subject><subject>Tenascin - biosynthesis</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpdUV1vEzEQtBCIhsIvQEJ-5OVa-_x15gEUJTRUagQS5dlyfHs9g-8c7Eur_HucplQFv6y1Mzs7q0HoLSVnlGh1vl6ekSePMkaeoRkVTFZCS_4czQipRaW04ifoVc4_DxxV85fopJa1lEypGRqXETK-htFm50fc21vAi-BH72zAl8M2lM_k45hxQb_ZqY8h3tyDq2RbwLHDq-DjYA-gh3HKnz7gOf6-zxMMpePwGiZbzUcb9tnn1-hFZ0OGNw_1FP24-Hy9-FJdfV1dLuZXlWNCqMq1G-kk4Ux3wlJhlRVUa1ZOIUxqKji0G1CaABE1EOcoo6LbkLZpGgINp-wUfTzqbnebAVpXjCUbzDb5waa9idabf5HR9-Ym3houqZRKFYH3DwIp_t5Bnszgs4MQ7Ahxlw1VxR3XmstCZUeqSzHnBN3jGkrMISmzXpr_kypT7546fJz5G00h8CPhLoYJUv4VdneQTA82TP29nlC6rmpCBWlITarSYYr9AXpMnl0</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Kong, Xiangyi</creator><creator>Ma, Wenbin</creator><creator>Li, Yongning</creator><creator>Wang, Yu</creator><creator>Guan, Jian</creator><creator>Gao, Jun</creator><creator>Wei, Junji</creator><creator>Yao, Yong</creator><creator>Lian, Wei</creator><creator>Xu, Zhiqin</creator><creator>Dou, Wanchen</creator><creator>Xing, Bing</creator><creator>Ren, Zuyuan</creator><creator>Su, Changbao</creator><creator>Yang, Yi</creator><creator>Wang, Renzhi</creator><general>Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150801</creationdate><title>Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis</title><author>Kong, Xiangyi ; Ma, Wenbin ; Li, Yongning ; Wang, Yu ; Guan, Jian ; Gao, Jun ; Wei, Junji ; Yao, Yong ; Lian, Wei ; Xu, Zhiqin ; Dou, Wanchen ; Xing, Bing ; Ren, Zuyuan ; Su, Changbao ; Yang, Yi ; Wang, Renzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3557-cdb6c60439f5a15a7a519937970369154edbe790e052e0cc1315fb0d8880e8413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Brain Neoplasms - pathology</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Neoplasm Grading</topic><topic>Prognosis</topic><topic>Systematic Review and Meta-Analysis</topic><topic>Tenascin - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Xiangyi</creatorcontrib><creatorcontrib>Ma, Wenbin</creatorcontrib><creatorcontrib>Li, Yongning</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Guan, Jian</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Wei, Junji</creatorcontrib><creatorcontrib>Yao, Yong</creatorcontrib><creatorcontrib>Lian, Wei</creatorcontrib><creatorcontrib>Xu, Zhiqin</creatorcontrib><creatorcontrib>Dou, Wanchen</creatorcontrib><creatorcontrib>Xing, Bing</creatorcontrib><creatorcontrib>Ren, Zuyuan</creatorcontrib><creatorcontrib>Su, Changbao</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Wang, Renzhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Xiangyi</au><au>Ma, Wenbin</au><au>Li, Yongning</au><au>Wang, Yu</au><au>Guan, Jian</au><au>Gao, Jun</au><au>Wei, Junji</au><au>Yao, Yong</au><au>Lian, Wei</au><au>Xu, Zhiqin</au><au>Dou, Wanchen</au><au>Xing, Bing</au><au>Ren, Zuyuan</au><au>Su, Changbao</au><au>Yang, Yi</au><au>Wang, Renzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>94</volume><issue>32</issue><spage>e1330</spage><epage>e1330</epage><pages>e1330-e1330</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Tenascin (TN) is an extracellular oligomeric glycoprotein that participates in the adhesion of cells to extracellular matrixc (ECM). Studies have shown that the expression levels of TN are upregulated in a variety of cancers, including colon cancer, lung cancer, brain tumor, and breast cancer. However, the implications and utilities of TN in clinical grading and prognosis of glioma patients were seldom reported and the effects of its pathway are still unclear and controversial. Thus, it is essential to carry out a meta-analysis to draw a convincing conclusion.A literature search was carried out up to April 2015. Data was collected using a purpose-designed form including glioma's WHO grade, etc. Differences were expressed as odds ratios (ORs) or standard mean differences (SMDs) with 95% confidence intervals (CIs). Galbr figure, Cochran's Q test, and I test were all performed to judge the heterogeneity between included studies. To examine the stability of the pooled results, a sensitivity analysis was performed. Potential publication bias was assessed by visual inspection of funnel plot. As this meta-analysis, as a systematic review, does not involve animal experiments or direct human trials, there is no need to conduct special ethic review and the ethical approval is not necessary.In this meta-analysis, 8 eligible studies involving 456 patients were incorporated. Six studies with dichotomous data revealed TN overexpression in glioma tissues and/or surrounding neoplastic vessels was closely associated with high WHO grade (III + IV) (odds ratio 3.398, 95% confidence interval 1.933, 5.974; P = 0.000); three continuous data studies showed there were close statistical associations between TN and WHO grade (SMD -2.114, 95% CI -2.580, -1.649; P = 0.000) too. Sensitivity analysis indicated a statistically robust result. No publication bias was revealed.Our meta-analysis suggests that TN expression is potentially associated with higher WHO grade of gliomas. More evidences on the basis of the evidence-based medicine are needed to prove it.</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>26266377</pmid><doi>10.1097/MD.0000000000001330</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0025-7974
ispartof Medicine (Baltimore), 2015-08, Vol.94 (32), p.e1330-e1330
issn 0025-7974
1536-5964
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4616677
source LWW_医学期刊; IngentaConnect Journals; PubMed Central
subjects Brain Neoplasms - pathology
Glioma - pathology
Humans
Neoplasm Grading
Prognosis
Systematic Review and Meta-Analysis
Tenascin - biosynthesis
title Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?: A Systematic Meta-Analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A23%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20Tenascin%20have%20Clinical%20Implications%20in%20Pathological%20Grade%20of%20Glioma%20Patients?:%20A%20Systematic%20Meta-Analysis&rft.jtitle=Medicine%20(Baltimore)&rft.au=Kong,%20Xiangyi&rft.date=2015-08-01&rft.volume=94&rft.issue=32&rft.spage=e1330&rft.epage=e1330&rft.pages=e1330-e1330&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000001330&rft_dat=%3Cproquest_pubme%3E1704349946%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3557-cdb6c60439f5a15a7a519937970369154edbe790e052e0cc1315fb0d8880e8413%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1704349946&rft_id=info:pmid/26266377&rfr_iscdi=true