Homeobox Genes are Expressed in the Retina and Brain of Adult Goldfish

The goldfish (Carassius auratus) visual pathway displays continuous growth and plasticity throughout life. Since homeobox genes are important transcriptional regulators in development, we searched for homeobox genes in the adult goldfish retina and brain. Using the PCR, we discovered a repertoire of...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1993-04, Vol.90 (7), p.2729-2733
Main Authors: Levine, Edward M., Schechter, Nisson
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Base Sequence
Biological and medical sciences
Brain
Brain - physiology
Carassius auratus
Cells
Cellular differentiation
Chickens - genetics
Cloning, Molecular
DNA - genetics
DNA - isolation & purification
Eye and associated structures. Visual pathways and centers. Vision
Fish
Freshwater
Fundamental and applied biological sciences. Psychology
Genes
Genes, Homeobox
Goldfish
Goldfish - genetics
Homeobox genes
Humans
Leeches - genetics
Molecular Sequence Data
Multigene Family
Neurons
Polymerase chain reaction
Polymerase Chain Reaction - methods
Retina
Retina - physiology
Ribonucleic acid
RNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Vertebrates
Vertebrates: nervous system and sense organs
Xenopus - genetics
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Summary:The goldfish (Carassius auratus) visual pathway displays continuous growth and plasticity throughout life. Since homeobox genes are important transcriptional regulators in development, we searched for homeobox genes in the adult goldfish retina and brain. Using the PCR, we discovered a repertoire of homeobox sequences expressed in these tissues. In addition to isolating homeodomain sequences found in the vertebrate Hox gene clusters, a sequence identical to the chicken CHox7 homeodomain was characterized. Furthermore, a sequence with significant homologies to the Xenopus XIHbox8 and leech Htr-A2 homeodomains was identified, and these sequences may define an additional class of homeodomain. Finally, a sequence belonging to the paired class (prd) of homeodomains is reported. Homeobox gene expression in the adult goldfish retina and brain may be associated with the persistent developmental features of these tissues.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.90.7.2729