Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses

Influenza is still a serious threat to human health with significant morbidity and mortality. The emergence of drug-resistant influenza viruses poses a great challenge to existing antiviral drugs. Traditional Chinese medicines (TCMs) may be an alternative to overcome the challenge. Here, 10 oral pro...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2015-01, Vol.2015 (2015), p.1-9
Main Authors: Jiang, Jian-Dong, Yin, Jin-Qiu, Wang, Hui-Qiang, Ge, Miao, Ma, Lin-Lin, Li, Yu-Huan
Format: Article
Language:English
Subjects:
Biological response modifiers
Disease control
Drug resistance
Drugs
Genomes
Health aspects
Infections
Influenza B virus
Influenza viruses
Ingredients
Interferon
Pharmaceuticals
Prevention
RNA polymerase
Science
Studies
Swine flu
Swine influenza
Viruses
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Summary:Influenza is still a serious threat to human health with significant morbidity and mortality. The emergence of drug-resistant influenza viruses poses a great challenge to existing antiviral drugs. Traditional Chinese medicines (TCMs) may be an alternative to overcome the challenge. Here, 10 oral proprietary Chinese medicines were selected to evaluate their anti-influenza activities. These drugs exhibit potent inhibitory effects against influenza A H1N1, influenza A H3N2, and influenza B virus. Importantly, they demonstrate potent antiviral activities against drug-resistant strains. In the study of mechanisms, we found that Xiaoqinglong mixture could increase antiviral interferon production by activating p38 MAPK, JNK/SAPK pathway, and relative nuclear transcription factors. Lastly, our studies also indicate that some of these medicines show inhibitory activities against EV71 and CVB strains. In conclusion, the 10 traditional Chinese medicines, as kind of compound combination medicines, show broad-spectrum antiviral activities, possibly also including inhibitory activities against strains resistant to available antiviral drugs.
ISSN:1741-427X
1741-4288
DOI:10.1155/2015/367250