Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone

Two patients, treated with acebutolol and amiodarone respectively, developed a disease clinically, radiologically, and pathologically indistinguishable from bronchiolitis obliterans organising pneumonia. In one case recovery followed discontinuation of acebutolol; in the other case cessation of amio...

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Bibliographic Details
Published in:Thorax 1989-09, Vol.44 (9), p.711-715
Main Authors: Camus, P, Lombard, J N, Perrichon, M, Piard, F, Guérin, J C, Thivolet, F B, Jeannin, L
Format: Article
Language:English
Subjects:
Acebutolol - adverse effects
Aged
Aged, 80 and over
Amiodarone - adverse effects
Biological and medical sciences
Biopsy
Bronchiolitis Obliterans - chemically induced
Bronchiolitis Obliterans - pathology
Drug toxicity and drugs side effects treatment
Humans
Lung - pathology
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pneumonia - chemically induced
Pneumonia - pathology
Toxicity: respiratory system, ent, stomatology
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Summary:Two patients, treated with acebutolol and amiodarone respectively, developed a disease clinically, radiologically, and pathologically indistinguishable from bronchiolitis obliterans organising pneumonia. In one case recovery followed discontinuation of acebutolol; in the other case cessation of amiodarone had no effect, and corticosteroids were required. In addition to these patients, several cases of bronchiolitis obliterans organising pneumonia have been reported during treatment with gold salts, amiodarone, and miscellaneous other drugs. Taken together, this information supports the view that bronchiolitis obliterans organising pneumonia may be a form of response by the lungs to insult by drugs.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.44.9.711