Irritable Bowel Syndrome: Peripheral Mechanisms and Therapeutic Implications

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, affecting about 10 to 20% of the population in developed countries. The mechanisms underlying the symptoms of this condition are poorly understood. Considered initially as the consequence of abnormal gut motility...

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Bibliographic Details
Published in:Clujul medical 2014, Vol.87 (2), p.73-79
Main Authors: Crisan, Iulia Maria, Dumitrascu, Dan Lucian
Format: Article
Language:English
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Summary:Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, affecting about 10 to 20% of the population in developed countries. The mechanisms underlying the symptoms of this condition are poorly understood. Considered initially as the consequence of abnormal gut motility, visceral hypersensitivity, psychosocial factors and brain-gut axis dysfunction, IBS is now acknowledged as a multifactorial disorder. Specific peripheral mechanisms are involved, including mucosal immune activation, increased intestinal permeability, enteroendocrine cell products, an excess of bile acids, gut dysbiosis. A better understanding of these mechanisms could help develop new and specific therapeutic pathways in patients suffering from IBS.
ISSN:2602-0807
1222-2119
2668-0572
2066-8872
DOI:10.15386/cjmed-269