Does the outcome of the tidal breathing and dosimeter methods of assessing bronchial responsiveness in children with asthma depend on age?

As minute volume increases with age, a study was carried out to determine whether the measurement of bronchial responsiveness to pharmacological agents with the tidal breathing technique in children might be influenced by age. Bronchial responsiveness to histamine administered by tidal breathing was...

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Bibliographic Details
Published in:Thorax 1990-03, Vol.45 (3), p.199-202
Main Authors: Birnie, D, thoe Schwartzenberg, G W, Hop, W C, van Essen-Zandvliet, E E, Kerrebijn, K F
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Allergic diseases
Asthma - physiopathology
Biological and medical sciences
Bronchi - drug effects
Bronchi - physiopathology
Bronchial Provocation Tests - methods
Child
Child, Preschool
Female
Histamine
Humans
Immunopathology
Male
Medical sciences
Respiratory and ent allergic diseases
Tidal Volume
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Summary:As minute volume increases with age, a study was carried out to determine whether the measurement of bronchial responsiveness to pharmacological agents with the tidal breathing technique in children might be influenced by age. Bronchial responsiveness to histamine administered by tidal breathing was therefore compared with that produced with a dosimeter in 25 children with asthma aged 5-18 years. Bronchial responsiveness was defined as the concentration of histamine that caused a 40% rise in pulmonary resistance (PC40) measured by random noise forced oscillation at 6 Hz. Values of PC40 measured by the tidal breathing method were lower than those obtained with the dosimeter method, presumably owing to differences in the dose administered and variations in the pattern of breathing. The difference between the two methods was not related to age, however. It is concluded that the tidal breathing and the dosimeter methods are both suitable for the measurement of bronchial responsiveness in children of various ages and that both can be used in longitudinal studies.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.45.3.199