Mindfulness-Based Stress Reduction to Enhance Psychological Functioning and Improve Inflammatory Biomarkers in Trauma-Exposed Women: A Pilot Study

This study examined the effects of a mindfulness-based stress reduction (MBSR) program on psychological functioning and inflammatory biomarkers in women with histories of interpersonal trauma. The 8-week MBSR program was conducted at a community-based health center and participants (N = 50) complete...

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Bibliographic Details
Published in:Psychological trauma 2015-11, Vol.7 (6), p.525-532
Main Authors: Gallegos, Autumn M., Lytle, Megan C., Moynihan, Jan A., Talbot, Nancy L.
Format: Article
Language:English
Subjects:
Adult
Anxiety - immunology
Anxiety - therapy
Biological Markers
Biomarkers - blood
Blood Chemical Analysis
Cytokines
Depression - immunology
Depression - therapy
Emotional Intelligence
Exposure
Female
Human
Humans
Inflammation
Interleukin-6 - blood
Interpersonal Relations
Linear Models
Mindfulness
Mindfulness - methods
Pilot Projects
Self Report
Socioeconomic Factors
Stress Management
Stress, Psychological - immunology
Stress, Psychological - therapy
Symptoms
Time Factors
Trauma
Treatment Outcome
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Summary:This study examined the effects of a mindfulness-based stress reduction (MBSR) program on psychological functioning and inflammatory biomarkers in women with histories of interpersonal trauma. The 8-week MBSR program was conducted at a community-based health center and participants (N = 50) completed several measures of psychological functioning at study entry as well as 4 weeks, 8 weeks, and 12 weeks later. Inflammatory biomarkers were assayed from blood collected at each assessment. A series of linear mixed-model analyses were conducted to measure the effect of attendance and time on the dependent variables. Time was associated with significant decreases in perceived stress, depression, trait and state anxiety, emotion dysregulation, and posttraumatic stress symptoms, as well as increases in mindfulness. Session attendance was associated with significant decreases in interleukin (IL)-6 levels. This pilot study demonstrated the potential beneficial effects of MBSR on psychological functioning and the inflammatory biomarker IL-6 among trauma-exposed and primarily low-income women. Decreases in inflammation have implications for this population, as interpersonal trauma can instigate chronic physiological dysregulation, heightened morbidity, and premature death. This study's preliminary results support efforts to investigate biological remediation with behavioral interventions in vulnerable populations.
ISSN:1942-9681
1942-969X
DOI:10.1037/tra0000053