A case of co-existing paraganglioma and thymoma

• Published in: SpringerPlus 2015-10, Vol.4 (1), p.632-632, Article 632
• Main Authors: Bano, G., Sennik, D., Kenchaiah, M., Kyaw, Ye, Snape, Katie, Tripathi, V., Wilson, P., Vlahos, I., Hunt, I., Hodgson, S.
• Format: Article
• Language: English
• Subjects: Case Study; Humanities and Social Sciences; Medicine; multidisciplinary; Science; Science (multidisciplinary)
• ISSN: 2193-1801; 2193-1801
• DOI: 10.1186/s40064-015-1269-z

Background Head and neck paragangliomas are rare tumours and can arise as a part of inherited syndromes. Their association with thymic tumour is not well known. Case description This report describes a female patient who presented with right sided neck paragangliomas. The histology of the tumour was consistent with paraganlioma. Few years later her MRI scan of the chest revealed presence of an anterior mediastinal mass that corresponded to the location of the thymus. Review of her previous scans showed that the mass was present all along and had gradually increased in size. Patient developed symptoms including fatigue, dyspnoea, migratory polyarthritis, Raynaud’s phenomenon and erythema nodosum. She had sternotomy and excision of mediastinal mass. The histology was consistent with cortical thymoma (WHO type B2) and she had radiotherapy. After treatment her constitutional symptoms improved. Her paraganglioma susceptibility genes are negative. Discussion and evaluation To our knowledge this is only the second case report in the literature of coexistence of carotid body tumour and thymoma. The first case reported was bilateral carotid body tumour, thyroid gland adenoma and thymoma. This case also highlights the importance of long term surveillance, multidisciplinary management and being aware of associated pathologies in patients with isolated paraganglioma.