Fosfomycin: Uses and Potentialities in Veterinary Medicine

Fosfomycin (FOS) is a natural bactericidal broad-spectrum antibiotic which acts on proliferating bacteria by inhibiting cell wall and early murein/peptidoglycan synthesis. Bactericidal activity is evident against Gram positive and Gram negative bacteria and can also act synergistically with other an...

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Bibliographic Details
Published in:Open veterinary journal (Tripoli, Libya) Libya), 2014-01, Vol.4 (1), p.26-43
Main Authors: Tapia , M. O, Pérez , D. S, Soraci , A. L
Format: Article
Language:English
Subjects:
Antibiotic
ANTIBIOTICS
Clinical uses
DRUGS
Fosfomycin
IMPACT ASSESSMENT
PHARMACODYNAMICS
Pharmacokinetics
Review
VETERINARY HYGIENE
الأدوية
الصحة البيطرية
المضادات الحيوية
تقييم الأثر
دراسة فعل العقاقير
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Summary:Fosfomycin (FOS) is a natural bactericidal broad-spectrum antibiotic which acts on proliferating bacteria by inhibiting cell wall and early murein/peptidoglycan synthesis. Bactericidal activity is evident against Gram positive and Gram negative bacteria and can also act synergistically with other antibiotics. Bacterial resistance to FOS may be natural or acquired. Other properties of this drug include inhibition of bacterial adhesion to epithelial cells, exopolysaccharide biofilm penetration, immunomodulatory effect, phagocytosis promotion and protection against the nephrotoxicity caused by other drugs. FOS has chemical characteristics not typically observed in organic phosphoric compounds and its molecular weight is almost the lowest of all the antimicrobials. It tends to form salts easily due to its acidic nature (disodium salt, for intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration; calcium and trometamol salt: for oral (PO) administration). FOS has a very low protein binding (
ISSN:2226-4485
2218-6050
2218-6050
DOI:10.12816/0027485