Inflammatory biomarkers in osteoarthritis

Summary Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite the global burden of OA, diagnostic tests and treatments for the molecular or early subclinical stages are still not available for clinical use. In recent years, there has been a large shift in the u...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2015-11, Vol.23 (11), p.1890-1896
Main Authors: Daghestani, H.N, Kraus, V.B
Format: Article
Language:English
Subjects:
Biomarker
Biomarkers - metabolism
Cytokines - biosynthesis
Cytokines - genetics
Gene Expression Regulation
Humans
Inflammation
Inflammation - metabolism
Osteoarthritis
Osteoarthritis, Knee - genetics
Osteoarthritis, Knee - metabolism
Rheumatology
RNA - genetics
Synovial Fluid - metabolism
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Summary:Summary Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite the global burden of OA, diagnostic tests and treatments for the molecular or early subclinical stages are still not available for clinical use. In recent years, there has been a large shift in the understanding of OA as a “wear and tear” disease to an inflammatory disease. This has been demonstrated through various studies using MRI, ultrasound, histochemistry, and biomarkers. It would of great value to be able to readily identify subclinical and/or sub-acute inflammation, particularly in such a way as to be appropriate for a clinical setting. Here we review several types of biomarkers associated with OA in human studies that point to a role of inflammation in OA.
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2015.02.009