Parental and comorbid epilepsy in persons with bipolar disorder

Abstract Background Population-based studies have demonstrated an overrepresentation of bipolar disorder (BPD) in individuals with epilepsy. However, few studies have examined the reverse association, i.e. comorbid epilepsy in individuals selected based on BPD diagnosis. No previous population-based...

Full description

Saved in:
Bibliographic Details
Published in:Journal of affective disorders 2015-12, Vol.188, p.107-111
Main Authors: Sucksdorff, Dan, Brown, Alan S, Chudal, Roshan, Jokiranta-Olkoniemi, Elina, Leivonen, Susanna, Suominen, Auli, Heinimaa, Markus, Sourander, Andre
Format: Article
Language:English
Subjects:
Adult
Bipolar disorder
Bipolar Disorder - epidemiology
Bipolar Disorder - psychology
Case-Control Studies
Causality
Child of Impaired Parents - psychology
Child of Impaired Parents - statistics & numerical data
Comorbidity
Epidemiology
Epilepsy
Epilepsy - epidemiology
Epilepsy - psychology
Female
Humans
Male
Middle Aged
Parental psychopathology
Parents - psychology
Population-based study
Psychiatry
Register
Risk Factors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Population-based studies have demonstrated an overrepresentation of bipolar disorder (BPD) in individuals with epilepsy. However, few studies have examined the reverse association, i.e. comorbid epilepsy in individuals selected based on BPD diagnosis. No previous population-based study having examined the co-occurrence of BPD and epilepsy has adjusted for parental psychopathology. Such an adjustment is motivated by population-based studies reporting an overrepresentation of various types of parental psychiatric disorders in both BPD and epilepsy. Furthermore, an association between epilepsy in first-degree relatives and BPD has previously only been examined and demonstrated in a small clinical sample. The objective of this study is to examine the associations between parental and comorbid epilepsy and BPD, adjusting for parental psychopathology. Methods This nested case-control study identified 1861 cases with BPD, age up to 25 years, 3643 matched controls, and their parents from Finnish national registers. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) and two-sided significance limits of p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2015.08.051