Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques

Highlights • We demonstrate that naltrexone reduces TLR2 expression in brain. • Naltrexone treatment reverses astrocyte atrophy associated with self-harm. • The number of potential synapses is dramatically increased following naltrexone.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.288-297
Main Authors: Lee, Kim M, Chiu, Kevin B, Didier, Peter J, Baker, Kate C, MacLean, Andrew G
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Astrocyte
Astrocytes - drug effects
Astrocytes - metabolism
Astrocytes - pathology
Atrophy
Behavior
Brain - drug effects
Brain - metabolism
Brain - pathology
Female
Glia
Gray Matter - drug effects
Gray Matter - pathology
Macaca
Macaca mulatta
Male
Naltrexone
Naltrexone - administration & dosage
Plasticity
Psychiatry
Self-Injurious Behavior - immunology
Self-Injurious Behavior - pathology
Self-Injurious Behavior - prevention & control
Self-injury
Toll-Like Receptor 2 - metabolism
White Matter - drug effects
White Matter - pathology
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Description
Summary:Highlights • We demonstrate that naltrexone reduces TLR2 expression in brain. • Naltrexone treatment reverses astrocyte atrophy associated with self-harm. • The number of potential synapses is dramatically increased following naltrexone.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.07.017