Animal models of human colorectal cancer:Current status,uses and limitations

AIM: To make orthotopic colon cancer murine modelsa more clearly understood subject. The orthotopic tumor models have been found to be more relevant in replicating the human disease process as compared to heterotopic models, many techniques for making orthotopic colorectal murine models have been re...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2015-11, Vol.21 (41), p.11854-11861
Main Authors: Mittal, Vijay K, Bhullar, Jasneet Singh, Jayant, Kumar
Format: Article
Language:English
Subjects:
Animals
cancer
cancer
Colon
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms - pathology
Colorectal Neoplasms - secondary
Heterografts
Humans
Liver Neoplasms - secondary
Lung Neoplasms - secondary
Lymphatic Metastasis
Mice
mode
model
Colon
Murine
Neoplasm Invasiveness
Neoplasm Transplantation
Neoplasms, Experimental - pathology
Neoplasms, Experimental - secondary
Systematic Reviews
Tumor Burden
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AIM: To make orthotopic colon cancer murine modelsa more clearly understood subject. The orthotopic tumor models have been found to be more relevant in replicating the human disease process as compared to heterotopic models, many techniques for making orthotopic colorectal murine models have been reported.METHODS: We evaluated the current literature for various reported orthotopic colon cancer models to understand their techniques, advantages and limitations. An extensive literature review was performed by searching the National Library of Medicine Database(Pub Med) using Me SH terms animal model; colon cancer; orthotopic model; murine model. Twenty studies related to colon cancer orthotopic xenograft model were evaluated in detail and discussed here. RESULTS: The detailed analysis of all relevant reports on orthotopic model showed tumor take rate between 42%-100%. While models using the enema technique and minimally invasive technique have reported development of tumor from mucosa with tumor take rate between 87%-100% with metastasis in 76%-90%.CONCLUSION: Over the years, the increased understanding of the murine models of human colon cancer has resulted in the development of various models. Each reported model has some limitations. These latest models have opened up new doors for continuing cancer research for not only understanding the colon cancer pathogenesis but also aid in the development of newer chemotherapeutic drugs as they mimic the human disease closely.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i41.11854