The uses of genome-wide yeast mutant collections

We assess five years of usage of the major genome-wide collections of mutants from Saccharomyces cerevisiae: single deletion mutants, double mutants conferring 'synthetic' lethality and the 'TRIPLES' collection of mutants obtained by random transposon insertion. Over 100 experime...

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Bibliographic Details
Published in:Genome biology 2004-01, Vol.5 (7), p.229-229
Main Authors: Scherens, Bart, Goffeau, Andre
Format: Article
Language:English
Subjects:
Genetics - trends
Genome, Fungal
Humans
Mutation - genetics
Review
Saccharomyces cerevisiae - genetics
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Summary:We assess five years of usage of the major genome-wide collections of mutants from Saccharomyces cerevisiae: single deletion mutants, double mutants conferring 'synthetic' lethality and the 'TRIPLES' collection of mutants obtained by random transposon insertion. Over 100 experimental conditions have been tested and more than 5,000 novel phenotypic traits have been assigned to yeast genes using these collections.
ISSN:1465-6906
1474-760X
1465-6914
DOI:10.1186/gb-2004-5-7-229