Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial

Highlights • The efficacy of buspirone for treatment of cannabis dependence was evaluated. • Buspirone provided no advantage over placebo in reducing cannabis use. • Women randomized to buspirone had worse cannabis use outcomes.

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Bibliographic Details
Published in:Drug and alcohol dependence 2015-11, Vol.156, p.29-37
Main Authors: McRae-Clark, Aimee L, Baker, Nathaniel L, Gray, Kevin M, Killeen, Therese K, Wagner, Amanda M, Brady, Kathleen T, DeVane, C. Lindsay, Norton, Jessica
Format: Article
Language:English
Subjects:
Adult
Alleles
Buspirone
Buspirone - administration & dosage
Buspirone - adverse effects
Buspirone - therapeutic use
Cannabinoids - blood
Cannabis
Combined Modality Therapy
Contingency management
Double-Blind Method
Female
Gender differences
Humans
Male
Marijuana Abuse - drug therapy
Marijuana Abuse - psychology
Motivation
Motivational enhancement therapy
Patient Compliance
Psychiatry
Psychotherapy
Receptor, Serotonin, 5-HT1A - genetics
Serotonin Receptor Agonists - administration & dosage
Serotonin Receptor Agonists - adverse effects
Serotonin Receptor Agonists - therapeutic use
Sex Characteristics
Treatment Outcome
Young Adult
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Description
Summary:Highlights • The efficacy of buspirone for treatment of cannabis dependence was evaluated. • Buspirone provided no advantage over placebo in reducing cannabis use. • Women randomized to buspirone had worse cannabis use outcomes.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.08.013