Normal Taste Acceptance and Preference of PANX1 Knockout Mice

Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 kno...

Full description

Saved in:
Bibliographic Details
Published in:Chemical senses 2015-09, Vol.40 (7), p.453-459
Main Authors: Tordoff, Michael G, Aleman, Tiffany R, Ellis, Hillary T, Ohmoto, Makoto, Matsumoto, Ichiro, Shestopalov, Val I, Mitchell, Claire H, Foskett, J Kevin, Poole, Rachel L
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Connexins - analysis
Connexins - deficiency
Connexins - metabolism
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins - analysis
Nerve Tissue Proteins - deficiency
Nerve Tissue Proteins - metabolism
Original
Taste - physiology
Taste Perception - physiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.
ISSN:0379-864X
1464-3553
DOI:10.1093/chemse/bjv025