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Normal Taste Acceptance and Preference of PANX1 Knockout Mice
Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 kno...
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| Published in: | Chemical senses 2015-09, Vol.40 (7), p.453-459 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 459 |
| container_issue | 7 |
| container_start_page | 453 |
| container_title | Chemical senses |
| container_volume | 40 |
| creator | Tordoff, Michael G Aleman, Tiffany R Ellis, Hillary T Ohmoto, Makoto Matsumoto, Ichiro Shestopalov, Val I Mitchell, Claire H Foskett, J Kevin Poole, Rachel L |
| description | Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1. |
| doi_str_mv | 10.1093/chemse/bjv025 |
| format | article |
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It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.</description><identifier>ISSN: 0379-864X</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bjv025</identifier><identifier>PMID: 25987548</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adenosine Triphosphate - metabolism ; Animals ; Connexins - analysis ; Connexins - deficiency ; Connexins - metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins - analysis ; Nerve Tissue Proteins - deficiency ; Nerve Tissue Proteins - metabolism ; Original ; Taste - physiology ; Taste Perception - physiology</subject><ispartof>Chemical senses, 2015-09, Vol.40 (7), p.453-459</ispartof><rights>The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>The Author 2015. Published by Oxford University Press. All rights reserved. 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It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Connexins - analysis</subject><subject>Connexins - deficiency</subject><subject>Connexins - metabolism</subject><subject>Female</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nerve Tissue Proteins - analysis</subject><subject>Nerve Tissue Proteins - deficiency</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Original</subject><subject>Taste - physiology</subject><subject>Taste Perception - physiology</subject><issn>0379-864X</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVkEtLw0AYRQdRbK0u3UqWbmLnPZOFQim-sNYuKnQXJpNvbGqSiZmk4L-34gNdXS4XzoGL0CnBFwQnbGzXUAUYZ5stpmIPDQmXPGZCsH00xEwlsZZ8NUBHIWwwJpxRfYgGVCRaCa6H6HLu28qU0dKEDqKJtdB0prYQmTqPFi04aOGzehctJvMViR5qb19930WPhYVjdOBMGeDkO0fo-eZ6Ob2LZ0-399PJLG5IIrtYG-ckoVzmKs-UI4xZZxgV0ihumZEaLOXO8ERSKS2x1DCraaJ0hq0Ey9gIXX1xmz6rILdQd60p06YtKtO-p94U6f-lLtbpi9-mXDIhmdwBzr8BrX_rIXRpVQQLZWlq8H1IicKCKyZ3B43Q2V_Xr-TnM_YBy35vLw</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Tordoff, Michael G</creator><creator>Aleman, Tiffany R</creator><creator>Ellis, Hillary T</creator><creator>Ohmoto, Makoto</creator><creator>Matsumoto, Ichiro</creator><creator>Shestopalov, Val I</creator><creator>Mitchell, Claire H</creator><creator>Foskett, J Kevin</creator><creator>Poole, Rachel L</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150901</creationdate><title>Normal Taste Acceptance and Preference of PANX1 Knockout Mice</title><author>Tordoff, Michael G ; Aleman, Tiffany R ; Ellis, Hillary T ; Ohmoto, Makoto ; Matsumoto, Ichiro ; Shestopalov, Val I ; Mitchell, Claire H ; Foskett, J Kevin ; Poole, Rachel L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-8aff61246d7db7f133cfa3256a74c3a68ec24fa496266c1c2a3c82978b0c6ec33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Connexins - analysis</topic><topic>Connexins - deficiency</topic><topic>Connexins - metabolism</topic><topic>Female</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Nerve Tissue Proteins - analysis</topic><topic>Nerve Tissue Proteins - deficiency</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Original</topic><topic>Taste - physiology</topic><topic>Taste Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tordoff, Michael G</creatorcontrib><creatorcontrib>Aleman, Tiffany R</creatorcontrib><creatorcontrib>Ellis, Hillary T</creatorcontrib><creatorcontrib>Ohmoto, Makoto</creatorcontrib><creatorcontrib>Matsumoto, Ichiro</creatorcontrib><creatorcontrib>Shestopalov, Val I</creatorcontrib><creatorcontrib>Mitchell, Claire H</creatorcontrib><creatorcontrib>Foskett, J Kevin</creatorcontrib><creatorcontrib>Poole, Rachel L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tordoff, Michael G</au><au>Aleman, Tiffany R</au><au>Ellis, Hillary T</au><au>Ohmoto, Makoto</au><au>Matsumoto, Ichiro</au><au>Shestopalov, Val I</au><au>Mitchell, Claire H</au><au>Foskett, J Kevin</au><au>Poole, Rachel L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal Taste Acceptance and Preference of PANX1 Knockout Mice</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem Senses</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>40</volume><issue>7</issue><spage>453</spage><epage>459</epage><pages>453-459</pages><issn>0379-864X</issn><eissn>1464-3553</eissn><abstract>Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25987548</pmid><doi>10.1093/chemse/bjv025</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0379-864X |
| ispartof | Chemical senses, 2015-09, Vol.40 (7), p.453-459 |
| issn | 0379-864X 1464-3553 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4635636 |
| source | Oxford Journals Online |
| subjects | Adenosine Triphosphate - metabolism Animals Connexins - analysis Connexins - deficiency Connexins - metabolism Female Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - analysis Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - metabolism Original Taste - physiology Taste Perception - physiology |
| title | Normal Taste Acceptance and Preference of PANX1 Knockout Mice |
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