Prevalence, associated factors and heritabilities of metabolic syndrome and its individual components in African Americans: the Jackson Heart Study

ObjectiveBoth environmental and genetic factors play important roles in the development of metabolic syndrome (MetS). Studies about its associated factors and genetic contribution in African Americans (AA) are sparse. Our aim was to report the prevalence, associated factors and heritability estimate...

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Bibliographic Details
Published in:BMJ open 2015-01, Vol.5 (10), p.e008675-e008675
Main Authors: Khan, Rumana J, Gebreab, Samson Y, Sims, Mario, Riestra, Pia, Xu, Ruihua, Davis, Sharon K
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
African Americans
Aged
Blood Glucose - genetics
Blood Glucose - metabolism
Blood Pressure - genetics
Body Mass Index
Cardiovascular disease
Cross-Sectional Studies
Epidemiology
Exercise
Female
Health risk assessment
Homocysteine - blood
Humans
Lipid Metabolism - genetics
Lipids - blood
Low density lipoprotein
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - ethnology
Metabolic Syndrome - etiology
Metabolic Syndrome - genetics
Middle Aged
Prevalence
Sex Factors
Smoking - adverse effects
Socioeconomic Factors
Stress, Psychological - complications
Waist Circumference - genetics
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Summary:ObjectiveBoth environmental and genetic factors play important roles in the development of metabolic syndrome (MetS). Studies about its associated factors and genetic contribution in African Americans (AA) are sparse. Our aim was to report the prevalence, associated factors and heritability estimates of MetS and its components in AA men and women.Participants and settingData of this cross-sectional study come from a large community-based Jackson Heart Study (JHS). We analysed a total of 5227 participants, of whom 1636 from 281 families were part of a family study subset of JHS.MethodsParticipants were classified as having MetS according to the Adult Treatment Panel III criteria. Multiple logistic regression analysis was performed to isolate independently associated factors of MetS (n=5227). Heritability was estimated from the family study subset using variance component methods (n=1636).ResultsAbout 27% of men and 40% of women had MetS. For men, associated factors with having MetS were older age, lower physical activity, higher body mass index, and higher homocysteine and adiponectin levels (p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-008675