"Clinicopathological features and treatment outcomes of differentiated thyroid cancer in Saudi children and adults"

Age is an important prognostic factor in differentiated thyroid cancer (DTC). Our aim was to evaluate differences in clinicopathological features and treatment outcomes among children and adult patients with DTC. We studied 27 children (below 18 years) with DTC treated during the period 2000-2012 an...

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Bibliographic Details
Published in:Journal of otolaryngology 2015-11, Vol.44 (48), p.48
Main Authors: Al-Qahtani, Khalid Hussain, Tunio, Mutahir A, Al Asiri, Mushabbab, Aljohani, Naji J, Bayoumi, Yasser, Riaz, Khalid, AlShakweer, Wafa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Care and treatment
Child
Child, Preschool
Development and progression
Disease-Free Survival
Female
Follow-Up Studies
Humans
Male
Neoplasm Staging
Original
Prognosis
Retrospective Studies
Saudi Arabia - epidemiology
Survival Rate - trends
Thyroid cancer
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy - methods
Treatment Outcome
Young Adult
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Summary:Age is an important prognostic factor in differentiated thyroid cancer (DTC). Our aim was to evaluate differences in clinicopathological features and treatment outcomes among children and adult patients with DTC. We studied 27 children (below 18 years) with DTC treated during the period 2000-2012 and were compared with (a) 78 adults aged 19-25 years and (b) 52 adults aged 26-30 years treated during the same period in terms of their clinicopathological features and long term treatment outcomes. Locoregional recurrence (LRR), locoregional control (LRC), distant metastasis (DM), distant metastasis control (DMC), disease free survival (DFS) and overall survival (OS) rates were evaluated. Mean age of children was 13.5 years (range: 5-18), while mean age of adults was 24.6 years (range: 19-30). In children, female: male ratio was 2.85:1, and in adults female: male ratio was 7.1:1 (P = 0.041). No significant difference in tumor size was seen between the two groups (P = 0.653). According to American Thyroid Association (ATA) risk stratification classification, the children (85.2 %) were found to have at high risk as compared to adults P = 0.001. Post-thyroidectomy complications and RAI induced toxicities were observed more in children than adults (P = 0.043 and P = 0.041 respectively). LRR occurred in 6 (22.2 %), 9 (11.5 %) and 3 (5.8 %) in age groups of
ISSN:1916-0216
1916-0208
1916-0216
DOI:10.1186/s40463-015-0102-6