Human recombinant-B-type natriuretic peptide protect ventricular function and structure in ST-elevation myocardial infarction

ST-elevation myocardial infarction (STEMI) is the most serious clinical type of coronary artery disease (CAD), which will lead to a loss of contractile function asa result of adverse left ventricular (LV) remodeling. Post-myocardial infarction remodeling is detrimental to the left ventricular functi...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (9), p.11622-11628
Main Authors: Gong, Xin, Mou, Zhengbin, Shao, Li, Zou, Yong, Gu, Youyi, Sun, Shaoli
Format: Article
Language:English
Subjects:
Aged
Echocardiography
Female
Heart Failure - drug therapy
Humans
Male
Middle Aged
Myocardial Infarction - physiopathology
Natriuretic Peptide, Brain - therapeutic use
Original
Peptide Fragments - therapeutic use
Recombinant Proteins
Ventricular Function - drug effects
Ventricular Function, Left - drug effects
Ventricular Remodeling - drug effects
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Summary:ST-elevation myocardial infarction (STEMI) is the most serious clinical type of coronary artery disease (CAD), which will lead to a loss of contractile function asa result of adverse left ventricular (LV) remodeling. Post-myocardial infarction remodeling is detrimental to the left ventricular function, which is strongly related to clinical outcome,including heart failure and cardiac death. And our study was designed to assess the efficacy of 72-hour IV infusion of rh-BNP therapy in STEMI patients with or without successful primary PCI, in preventing adverse LV remodeling and preserving LV function. 100 patients diagnosed as STEMI combined with acute heart failure (Killip classification ≥ 2) were recorded. And they were divided into "rh-BNP treatment group" (n=50) and "control group" (n=50). In addition to conventional heart failure therapy, patients in the rh-BNP group received rh-BNP infusion for 72 hours. All patients were followed up at 3 month after discharge. Their medical history was taken, as well as the presence or absence of relevant symptoms. 6-minute walking test, as well as echocardiographic indexes were recorded to evaluate the improvement of cardiac function. The data analysis about demographic comparison, including those related complicated diseases among groups showed no significant difference. After the follow-up, the indicators were all better than baseline among four subgroups (all P
ISSN:1936-2625