Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats

The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba goats in order to evaluate the properties of gastric emptying. Acetaminophen was intravenously and orally administered at 30 mg/kg body weight to goats using a crossover design with a 3-week washout period. The sta...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2015, Vol.77(10), pp.1331-1334
Main Authors: ELBADAWY, Mohamed, SASAKI, Kazuaki, MIYAZAKI, Yuji, ABOUBAKR, Mohamed, KHALIL, Waleed Fathy, SHIMODA, Minoru
Format: Article
Language:English
Subjects:
acetaminophen
Acetaminophen - administration & dosage
Acetaminophen - pharmacokinetics
Administration, Oral
Animals
Area Under Curve
Biological Availability
gastric emptying
Gastric Emptying - physiology
goat
Goats - physiology
Half-Life
Injections, Intravenous
oral absorption
pharmacokinetics
Pharmacology
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Summary:The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba goats in order to evaluate the properties of gastric emptying. Acetaminophen was intravenously and orally administered at 30 mg/kg body weight to goats using a crossover design with a 3-week washout period. The stability of acetaminophen in rumen juice was also assessed. Acetaminophen concentrations were measured by HPLC. Since acetaminophen was stable in rumen juice for 24 hr, the extremely low bioavailability (16%) was attributed to its hepatic extensive first-pass effect. The mean absorption time and absorption half-life were unexpectedly short (4.93 and 3.35 hr, respectively), indicating its marked absorption from the forestomach, which may have been due to its smaller molecular weight. Therefore, acetaminophen was considered to be unsuitable for evaluating gastric emptying in Shiba goats.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.15-0104